Description
Featuring an industry-leading low-dispersion design, the Nexera X4 UHPLC delivers superior sensitivity, ultra-sharp peaks and outstanding separation performance. Advanced fluid control technology maintains exceptional flow stability during high-speed, ultra-high-pressure analyses for consistently reliable results.
Features of the Nexera X4 UHPLC include:
- Ultra-Fast Analysis - With a new four-drive binary pump, independently activated plungers and pressure feedback control, the Nexera X4 UHPLC enables ultra-fast analysis through highly responsive solvent delivery. The instrument cuts analysis times by 92% versus typical HPLC systems and 78% versus other UHPLC-class systems, delivering up to 14 times greater laboratory productivity.
-
High-End Autosampler - Features a newly designed low-internal-volume high-pressure valve, low-dispersion injection mode, and high-speed needle internal/external rinsing, making it suitable for a wide range of samples, from those with extremely low concentrations that require high sensitivity to samples with high concentrations that require rinsing functionality.
-
Newly Designed Low-Dispersion, High-Sensitivity PDA Detector - The new SPD-M40 X4 uses a capillary cell to reduce peak broadening, a design that minimizes solvent-derived refractive index effects, leading to stable baselines and higher sensitivity. In addition, the broader dynamic range enables analysis of a wider range of low to high-concentration samples.
-
Ultra-Sharp Peaks - The Nexera X4 incorporates Shimadzu’s Nexflow technology to minimize system-derived peak broadening through low-dispersion flow paths that maintain the internal diameter of the flow lines. This feature increases sensitivity, enables full UHPLC column performance and delivers higher separation efficiency.
-
Ultra-Low Solvent Consumption - Used with narrow-bore columns, the Nexera X4 UHPLC significantly reduces solvent consumption, enabling more cost-efficient and environmentally conscious analysis.
-
Optimized for Analytical Miniaturization - The Nexera X4 UHPLC supports analytical miniaturization through its precise micro-volume injection, accurate mobile phase delivery and low-dispersion flow paths that minimize band broadening, even with narrow-bore columns.
-
Maximize Mass Spectrometry Performance - The Nexflow Tubing kit reduces peak broadening between the column outlet and MS interface, leveraging the ultra-fast and high-separation performance of the Nexera X4 UHPLC and maximizing mass spectrometer performance.
Analytical Intelligence to Maintain System Robustness
Three key functionalities serve to maintain analytical robustness:
- During startup, the system checks the status of the check valve and autosampler, preventing analysis if any issues are detected.
-
Safeguards data quality by stabilizing flow and protecting against column degradation.
-
Continuously monitors operations during analyses, automatically restoring functionality and minimizing downtime in case of problems.