Description
InformationCyclosporin A (NSC 290193) Cyclosporin A (Cyclosporine A, Cyclosporine, Ciclosporin, CsA) is an immunosuppressive agent, binds to the cyclophilin and then inhibits calcineurin with IC50 of 7 nM in a cell-free assay, widely used in organ transplantationIn vitroCyclosporin A binds to the cyclophilin (immunophilin) in T cells, forms a Cyclophilin-Cyclosporin A complex which the binds to and inhibits calcineurin. Cyclosporin A inhibits calcineurin with IC50 of 7 nM, then blocks the nuclear translocation of NF-AT. Cyclosporin A also affects mitochondria by preventing the MTP (mitochondrial permeability transition pore) from opening with an IC50 of 39 nM.In vivoCyclosporin A is an immunosuppressive agent that is effective following either parenteral or oral administration in mice, rat and guinea pigs., is clinically used in organ transplantation to prevent rejection.Cell Datacell lines：Concentrations：~100 nMIncubation Time：1 hrPowder Purity:≥99%