Antibody–drug conjugates such as Kadcyla require analytical platforms capable of dissecting extensive structural heterogeneity, quantifying variable drug-to-antibody ratios, and resolving conjugation events across numerous lysine sites. The Thermo Scientific™ Orbitrap™ Excedion™ Pro Biopharma hybrid mass spectrometer delivers critical advancements for these challenges, including an extended mass range for native intact DAR analysis, high-speed EThcD fragmentation that preserves linker–payload integrity, and enhanced dynamic range enabling detection of low-abundance modifications. These capabilities support confident conjugation-site localization, complete sequence coverage, and differentiation of subtle PTMs—including low-level isoaspartic acid.

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