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 In this study, we examined the impact of GC column deactivation on lowering detection limits for semivolatiles analysis when using GC-MS/MS. The MDLs and LLOQs generated using an RMX-5Sil MS column were found to be significantly lower for approximately two thirds of the compounds tested compared to results obtained on a premium competitor column. Better sensitivity was achieved for a wide range of compound chemistries due to the more effective deactivation used in RMX-5Sil MS columns.

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