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Sample concentration and buffer exchange are persistent bottlenecks in biomolecule purification, directly impacting yield, time, and cost. Current lab methods force a compromise:

  • Dead-end ultrafiltration fouls quickly, loses sample, and demands hands-on monitoring.
  • Equilibrium dialysis is gentle but takes 8–12 hours and still requires a separate concentration step.
  • Industrial TFF avoids these issues but has dead volumes far too large for lab-scale work.

This application note introduces µPulse®, a miniaturized TFF system that closes the gap. Readers will see how microfluidic-integrated filter chips deliver 4x faster concentration, 90–99% sample recovery, and fully walk-away operation in a lab-friendly footprint.

 

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