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Magnetic bead-based DNA purification is the go-to method for nucleic acid cleanup — but conventional pipetting introduces avoidable costs and inconsistencies:

  • Viscous bead suspensions stick to tips, producing non-uniform dispensing and variable yields.
  • Contact pipetting drives bead carryover and cross-contamination, forcing fresh tips at every step.
  • Tip consumption inflates operating costs and plastic waste across every 96-well plate processed.

This application note presents a semi-automated, tip-free workflow that pairs MANTIS® non-contact dispensing with Blue®Washer centrifugal evacuation. Readers will see how the combination reduces hands-on time and tip consumption by 83%, eliminates bead carryover, and improves reproducibility across the full bind-wash-elute process.

 

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