Oct. 23, 2012: Avacta Analytical’s Optim® 1000 – a unique high throughput, micro-volume protein analysis and characterisation system – is proving a valuable asset to scientists at the Macromolecule and Vaccine Stabilization Center (MVSC), University of Kansas, USA. Professor C. Russell Middaugh explained: “Conventional analytical techniques used in preformulation, stability and formulation studies rely on methods that extrapolate partial data on slow and labour‑intensive instrumentation, making them incompatible with high throughput measurements and tight development timelines. We have developed a faster and more comprehensive approach, which depends on the measurement of all potential variables. The results are then processed mathematically using specially developed software, and are represented visually using empirical phase diagrams.”
“Ideally, a replicate series of results is acquired for each parameter and, although a variety of instruments can be used for individual measurements, this type of equipment tends to rely on relatively time-consuming processes and can generally handle only low throughputs. Sample volume is also an issue, since many conventional techniques require large amounts of the target molecule. The Optim 1000 provides rapid, multi-modal analysis of ultra-low sample volumes at high throughputs, precisely the kind of replicate measurements we need to generate data in a timely manner. Combining multiple technologies in a single instrument is already making in-roads into preformulation and formulation studies, and this approach is proving a real asset to researchers involved in the drug development process.”
For more information, visit http://www.avactaanalytical.com/optim-1000
About Avacta Analytical
Avacta Analytical provides services and innovative instrumentation to the biopharmaceutical market. Our focus is to equip customers with a broad range of capabilities, enabling them to develop their therapeutics quicker, cheaper and better.
The groundbreaking Optim 1000 is an innovative analytical instrument designed to probe multiple stability-indicating parameters at high speed using ultra-low sample volumes of proteins and other molecules.
Our services business specialises in supporting characterisation, formulation, comparability and stability studies of therapeutic proteins. We are able to draw upon a wide range of analytical capabilities and aim to give our customers a flexible value-added service.
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