New media prep station from Copley Scientific increases productivity in tablet dissolution testing

New media prep station from Copley Scientific increases productivity in tablet dissolution testing

18 July 2013: Nottingham, UK: The new Dissomate media preparation unit from Copley Scientific is an automated, compact system for preparing and gravimetrically dispensing the pre-warmed, de-aerated, dosed dissolution media required for accurate tablet dissolution testing. Operating on the ³filtering, warming, and stirring under vacuum principle² recommended by the pharmacopoeias and FDA, it can prepare 8 litres of fresh dissolution media in under 15 minutes. These fast preparation times in combination with rapid dispensing reduce the down time between dissolution experiments, with proven savings compared with manual preparation.

Dissolution testing is vital in tablet manufacture. Accurate analysis requires well-prepared dissolution media as air bubbles and other dissolved gases are widely recognised as sources of problems. Efficiently producing warmed, degassed dissolution media ensures productive operation of a dissolution testing lab, and the integrity of the resulting data.

The Copley Scientific Dissomate combines preparation and dispensing in a single unit. It warms and degasses the medium in accordance with the procedures defined in the pharmacopoeias, and then dispenses on the basis of weight. Gravimetric dispensing avoids the issues known to be associated with volumetric filling when the standard filling temperature (25oC) differs from the temperature on dispensing (37oC ), and is recommended by the US pharmacopoeia for its superior accuracy.

Automatic addition of the required volume of acid, buffer or surfactant prior to mixing and dispensing eliminates any requirement for pre-preparation while the unit¹s remote dispensing gun allows in situ filling, avoiding any need to transport the dissolution vessels. The standard 8 L Dissomate supports several dissolution testers but a larger 15 L version is available on request. This can fill two complete dissolution testers from a single preparation process.

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About Copley Scientific

Copley Scientific is recognised as the world¹s leading manufacturer and supplier of inhaler test equipment and is a major provider of testing systems for other pharmaceutical dosage forms. The company is also active in detergent testing, air sampling and aerosol characterisation.

Copley Scientific¹s pharmaceutical product range includes test equipment for: delivered dose uniformity and aerodynamic particle size measurement of metered-dose inhalers, dry powder inhalers, nebulizers and nasal sprays; as well as tablets (dissolution, disintegration, friability and hardness) capsules, powders, suppositories and transdermals.

Copley Scientific has offices in the UK and Switzerland. The company works in partnership with aerosol particle science experts MSP Corporation in North America, and also distributes MSP Corporation¹s air sampling and aerosol characterisation products throughout Europe.

Serving the pharmaceutical and associated industries, Copley Scientific offers an extensive range of equipment for research, development and quality control, as well as full validation and aftersales services. This broad range of products is supplied and supported worldwide through a network of specialist distributors.