Liquid Handling Robotics (Automated Systems)

• Designed for biochemical and genomic sample and reagent transfer
• Improve data quality while saving on reagent costs
• Reagent reservoir for larger volume reagent transfers

• Highly precise and accurate low volume

• Designed for biochemical and genomic sample and reagent transfer
• Improve data quality while saving on reagent costs
• Reagent reservoir for larger volume reagent transfers

• Highly precise and accurate low volume transfers enabling assay miniaturization
• Builds assays 50–100 times faster than traditional liquid handlers giving the lab higher capacity from one instrument
• Suite of Echo Software Applications guide creation of complex protocols for a variety of applications
• Eliminates pipetting variances that affect assay success
• Integrates into the Labcyte Access Laboratory Workstation for increased throughput

The flexibility, speed, accuracy, and precision of the Echo 525 Liquid Handler enable researchers to build assays that are not possible with traditional liquid handlers. The use of acoustic sound energy removes the traditional boundaries of tip and pin tool based liquid handlers. Transfer variable fluid heights and viscosities from one source plate to enable rapid assay creation in one fluid transfer run. Say goodbye to fixed plate designs as the Echo Liquid Handler moves fluids from any well to any well enabling researchers to design the experimental plates they need to make new discoveries.

Assay assembly and the transfer of one reagent to many wells is simplified using the Echo Qualified Reservoir. With the capability of transferring up to 2.5 µL from each micro-well, you can build your assay without requiring an instrument change – saving time and money.

The Echo 525 Liquid Handler transfers a wide range of fluids during one transfer including distilled water, buffers, nucleic acids, and reagents containing up to 50% glycerol. With its versatile fluid range, transfer volume range, any well to any well transfer capability, and powerful applications software the Echo 525 Liquid Handler supports a wide range of genomic assay workflows:

• Gene Synthesis
• PCR and qPCR assay set-up
• RNA and DNA NGS sequencing workflows
• Sanger sequencing assay set-up
• Single-cell sample preparation

Perform online cultivation experiments and prepare media compositions with the BioLector XT microbioreactor & Biomek i5 liquid handler integration. Our unique automated screening platform for microbial cultures allows you to

Perform online cultivation experiments and prepare media compositions with the BioLector XT microbioreactor & Biomek i5 liquid handler integration. Our unique automated screening platform for microbial cultures allows you to design and execute highly elaborate experiments that are on track with biological signals increasing the experiment reproducibility. Individually triggered sampling, dosing actions (e.g., adding inducer or feed solutions), or inoculation of culture wells in the BioLector XT microplate are executed on the basis of the online, real-time signals from the BioLector XT microbioreactor (biomass, pH value, dissolved oxygen concentration, experiment time, etc.) without the need to stop the shaking of the microplate inside the BioLector XT instrument.

• Measure biomass, pH value, dissolved oxygen and fluorescence online
• Increased walk-away time
• Reduce potential contamination with automation
• Reliable scale-up to benchtop fermenters
• Reproducibility and scalability of results

The system automatically draws samples, adds media and inducer solutions or inoculates the culture wells triggered by experiment time or BioLector XT microbioreactor online signals. This allows for an increased walk-away time while keeping the same level of quality output.

Take advantage of the integrated system to transform your workflow and get reproducible experiment data. The scalable results make it fast and easy to bring more products to market.

Incorporating cultivation modes with online triggers (real-time signals from the BioLector XT microbioreactor), you get the benefits of continuous operation 24/7.

Fixed Biomek tips are cleaned and decontaminated between actions reducing the potential for cross-contamination.

• DO or time controlled feeding
• Fed-batch with bolus feeding
• Repeated fed-batch
• Biomass dependent sampling or dosing
• Time dependent sampling or dosing
• pH adjustments

• Biomass concentration
• pH, DO (using optodes)
• Fluorescent molecules (GFP, YFP, DsRed ...)
• NAD(P)H and riboflavins
• Process or induction time
• Working volume

• Automated upstream processing of up to 48 parallel cultivations
• Continuous operation 24 hours/day and 7 days/week
• Plug & Play disposable technology
• Design of experiments (DoE)• Detailed process understanding in short time
• Excellent pipetting accuracy (< 5 %, 50 - 950 µl) and reproducibility (CV < 5 %, 50 - 950 µl)
• Reliable scale-up to lab-fermenters
• Fast and easy data analysis
• A valuable tool for PAT and QbD
• Processing units possible (for custom made solutions)

• Automated sampling
• Automated induction
• Induction profiling
• Synchronized process manipulation
• pH profiling
• Feeding profiling
• Media preparation
• Process characterization
• High-throughput protein expression
• Automated upstream processing with microbial cultures