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| Company | Beckman Coulter Life Sciences | Beckman Coulter Life Sciences | Beckman Coulter Life Sciences |
| Item | RoboLector Platform | BioLector XT Microbioreactor & Biomek i5 Liquid Handler Integration | Cydem VT Automated Clone Screening System |
| Catalog Number | RoboLector | BioLector XT + Biomek i5 | Cydem VT |
| Price | | | |
| Description | RoboLector Platform Overview
The RoboLector XL system is an automated fermentation platform which combines the high-throughput fermentation and online monitoring capability of the BioLector XT microbioreactor with the precise and accurate liquid handling of a robotic system.
The RoboLector system RoboLector Platform Overview
The RoboLector XL system is an automated fermentation platform which combines the high-throughput fermentation and online monitoring capability of the BioLector XT microbioreactor with the precise and accurate liquid handling of a robotic system.
The RoboLector system autonomously prepares media compositions, among others, from the design of experiments (DoE) tests, followed by an online-monitored high-throughput cultivation.
Furthermore, pH adjustments can be made and inducers as well as feed solutions can be added to each cultivation well according to a pre-defined schedule or triggered by online process signals. Automated sampling into various targets including a cooling station facilitates optimal process monitoring and control.
Features of the RoboLector XL
Cultivation Modes - DO or time controlled feeding
- Fed-batch with bolus feeding
- Repeated fed-batch
- Biomass dependent sampling or dosing
- Time dependent sampling or dosing
- pH adjustments
Online Trigger Signals - Biomass concentration
- pH, DO (using optodes)
- Fluorescent molecules (GFP, YFP, DsRed ...)
- NAD(P)H and riboflavins
- Process or induction time
- Working volume
Advantages - Automated upstream processing of up to 48 parallel cultivations
- Continuous operation 24 hours/day and 7 days/week
- Plug & Play disposable technology
- Design of experiments (DoE)• Detailed process understanding in short time
- Excellent pipetting accuracy (< 5 %, 50 - 950 µl) and reproducibility (CV < 5 %, 50 - 950 µl)
- Reliable scale-up to lab-fermenters
- Fast and easy data analysis
- A valuable tool for PAT and QbD
- Processing units possible (for custom made solutions)
Applications - Automated sampling
- Automated induction
- Induction profiling
- Synchronized process manipulation
- pH profiling
- Feeding profiling
- Media preparation
- Process characterization
- High-throughput protein expression
- Automated upstream processing with microbial cultures
... Read More | BioLector XT Microbioreactor & Biomek i5 Liquid Handler Integration
Perform online cultivation experiments and prepare media compositions with the BioLector XT microbioreactor & Biomek i5 liquid handler integration. Our unique automated screening platform for microbial cultures allows you to BioLector XT Microbioreactor & Biomek i5 Liquid Handler Integration
Perform online cultivation experiments and prepare media compositions with the BioLector XT microbioreactor & Biomek i5 liquid handler integration. Our unique automated screening platform for microbial cultures allows you to design and execute highly elaborate experiments that are on track with biological signals increasing the experiment reproducibility. Individually triggered sampling, dosing actions (e.g., adding inducer or feed solutions), or inoculation of culture wells in the BioLector XT microplate are executed on the basis of the online, real-time signals from the BioLector XT microbioreactor (biomass, pH value, dissolved oxygen concentration, experiment time, etc.) without the need to stop the shaking of the microplate inside the BioLector XT instrument. - Measure biomass, pH value, dissolved oxygen and fluorescence online
- Increased walk-away time
- Reduce potential contamination with automation
- Reliable scale-up to benchtop fermenters
- Reproducibility and scalability of results
BioLector XT Microbioreactor & Biomek i5 Liquid Handler Integration Features
Automation
The system automatically draws samples, adds media and inducer solutions or inoculates the culture wells triggered by experiment time or BioLector XT microbioreactor online signals. This allows for an increased walk-away time while keeping the same level of quality output. Reproducibility and Scalability
Take advantage of the integrated system to transform your workflow and get reproducible experiment data. The scalable results make it fast and easy to bring more products to market. Software
Incorporating cultivation modes with online triggers (real-time signals from the BioLector XT microbioreactor), you get the benefits of continuous operation 24/7. Reduce Contamination Risk
Fixed Biomek tips are cleaned and decontaminated between actions reducing the potential for cross-contamination. ... Read More | The Cydem VT Automated Clone Screening System combines multiple trusted Beckman Coulter technologies into one advanced platform that empowers lab managers with a far more effective, high-throughput method—offering increased confidence that promising clones don’t get overlooked in the process of The Cydem VT Automated Clone Screening System combines multiple trusted Beckman Coulter technologies into one advanced platform that empowers lab managers with a far more effective, high-throughput method—offering increased confidence that promising clones don’t get overlooked in the process of consistently selecting the best.
- High-throughput clone screening in cell line development
- Automated, walk-away operation
- All results in one software
- pH-controlled fed-batch cultivation of 96 parallel clones with individual gassing
- On-deck cell count, viability and antibody titer analysis
- Fully integrated system
... Read More |
| Volume | Inquire | Volume (cultivation well) 800 to 2400 µL (depending on microtiter plate type) | Inquire |
| Applications | Automated sampling, automated induction, induction profiling, synchronized process manipulation, pH profiling, feeding profiling, media preparation, process characterization, high-throughput protein expression, and automated upstream processing with microbial cultures | Automated sampling/harvesting, automated inoculation of cultivation wells, automated induction, bolus feeding / repeated fed-batch, induction profiling, microbial growth synchronization, feed profiling, media preparation, and automated upstream processing with microbial cultures | Top clone screening in Cell Line Development |
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