Ultra high-performance liquid chromatography, UHPLC, uses columns packed with porous sub-2-µm particles (usually 1.8 µm) to vastly increase throughput and resolving power compared to conventional 5-µm columns. Pressures can surpass 19,000 psi. Limited solvent consumption, the ability to work under a broader pressure range, and lower band broadening are further enhancements. UHPLC’s 10× reduction in analysis time strengthens its popularity in areas including the pharmaceutical industry, food safety, and the clinical field.
The choice of detectors for use with UHPLC is wide-ranging, including UV-VIS, fluorescence, photodiode array, ELSD, quadrupole, and most recently, refractive index. For flexibility, many instruments offer the ability to run both conventional and UHPLC on one instrument. A final tip: When making the switch from HPLC to UHPLC, resist the temptation to overload the smaller columns.
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Thermo Fisher Scientific
- Charged Aerosol Detector (CAD), Diode Array Detector (DAD), Fluorescence Detector (FLD), Multiple Wavelength Detector (MWD), Variable Wavelength Detector (VWD), Refractive Index Detector (RI), Mass Spectrometer
- 0–10 mL/min
- 700 bar
Thermo Fisher Scientific
- Charged Aerosol Detector (CAD), Diode Array Detector (DAD), Fluorescence Detector (FLD), Multiple Wavelength Detector (MWD), Variable Wavelength Detector (VWD), Refractive Index Detector (RI), Mass Spectrometer
- 0–5, 0–8, or 0–10 mL/min (depends on pumps selected)
- 700–1500 bar (depends on configuration)
Thermo Fisher Scientific
- Charged Aerosol Detector (CAD), Diode Array Detector (DAD), Fluorescence Detector (FLD), Multiple Wavelength Detector (MWD), Variable Wavelength Detector (VWD), Refractive Index Detector (RI), Mass Spectrometer
- 0–5 or 0–8 mL/min (depends on pumps selected)
- 1000 or 1500 bar (depends on configuration)
Thermo Fisher Scientific
- Charged Aerosol Detector (CAD), Diode Array Detector (DAD), Fluorescence Detector (FLD), Multiple Wavelength Detector (MWD), Variable Wavelength Detector (VWD), Refractive Index Detector (RI), Mass Spectrometer
- 0–5, 0–8, or 0–10 mL/min (depends on pumps selected)
- 700, 1000, or 1500 bar (depends on configuration)
Thermo Fisher Scientific
- Charged Aerosol Detector (CAD), Diode Array Detector (DAD), Fluorescence Detector (FLD), Multiple Wavelength Detector (MWD), Variable Wavelength Detector (VWD), Refractive Index Detector (RI), Mass Spectrometer
- 0–5 or 0–8 mL/min (depends on pumps selected)
- 1500 bar
Thermo Fisher Scientific
- Inquire
- 8 mL/min
- up to 1000 bar (15,000psi)
Thermo Fisher Scientific
- Inquire
- 8 mL/min
- up to 1000 bar (15,000psi)
Thermo Fisher Scientific
- Inquire
- 8 mL/min
- Up to 1500 bar (22,000 psi)
Thermo Fisher Scientific
- Diode Array
- 8 mL/min
- up to 1000 bar (15,000psi)
Select up to 5 products from above to compare or request more information.
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