| Description | iNeu™ human keratinocytes are derived from human dermal fibroblasts, using a feeder-free, serum-free, genetic-free, virus-free induced pluripotent stem cell (iPSC) line, and have fully defined proprietary induction and maturation conditions. iNeu™ cells can be cultured in a monolayer andiNeu™ human keratinocytes are derived from human dermal fibroblasts, using a feeder-free, serum-free, genetic-free, virus-free induced pluripotent stem cell (iPSC) line, and have fully defined proprietary induction and maturation conditions. iNeu™ cells can be cultured in a monolayer and can express different biomarkers, such as Cytokeratin-18. iNeu™ can be used under mature conditions, co-culture conditions (used with fibroblasts, melanocytes or other epidermal subtypes), and short-term functional characterization studies.... Read More | Human iPSC-Derived Neural Stem Cells that have been genetically edited using CRISPR-Cas9 technology to introduce the P301L mutation (CCG>CTG) into the MAPT gene. This line is homozygous for the P301L mutation so both alleles contain the mutation. Click on the product images to see the data and Human iPSC-Derived Neural Stem Cells that have been genetically edited using CRISPR-Cas9 technology to introduce the P301L mutation (CCG>CTG) into the MAPT gene. This line is homozygous for the P301L mutation so both alleles contain the mutation. Click on the product images to see the data and further details.
The P301L mutation MAPT has been implicated in frontotemporal dementia and parkinsonism (Dumanchin et al., 1998). The mutation affects only the 4R isoforms of MAPT since the exon containing the mutation is spliced out of 3R isoforms (Hutton et al., 1998). Aggregated MAPT/tau protein in affected patients consisted mainly of the 4R isoform (Hutton et al., 1998). The P301L mutation promotes aggregation of MAPT/tau protein into ordered paired helical filaments and beta sheet formation in vitro (von Bergen et al., 2001).... Read More | iNeuO2™ is a fluorescent biosensor that has been integrated into iNeuRapid™, iNeu's proprietary immortalized human neuroepithelial cell line. Biosensor assays provide fast kinetics (resolution: several seconds to several hours) when measuring real-time cell metabolism and cytotoxicity. iNeuO2™ is a fluorescent biosensor that has been integrated into iNeuRapid™, iNeu's proprietary immortalized human neuroepithelial cell line. Biosensor assays provide fast kinetics (resolution: several seconds to several hours) when measuring real-time cell metabolism and cytotoxicity. The analysis of cell respiration directly reflects the health and function of mitochondria.
iNeuO2™-Rapid cells can be used as a control for all products containing iNeuO2™ biosensor. In order to customize iNeuRapid™ cells according to the experimental needs of scientists, these cells can be easily transfected with the target gene. For other human cell lines and human cell types, please contact us.... Read More | Creative Biolabs offers a range of recombinant cell lines for Immunotherapy discovery and development. | Creative Biolabs' Neuropathy Frozen Tissue Panels are designed for the study of Alzheimer's disease, Parkinson's disease, dementia, multiple sclerosis, progressive supranuclear palsy (PSP) and depression. |