| Description | Bifidobacterium are Gram-positive, heterofermentative, anaerobic bacteria with a distinctive bifid; i.e. Y shape after which they are named. They wre originally isolated from the faeces of breast-fed infants, members of the genus Bifidobacterium are commonly found in the GI tract of mammals. In Bifidobacterium are Gram-positive, heterofermentative, anaerobic bacteria with a distinctive bifid; i.e. Y shape after which they are named. They wre originally isolated from the faeces of breast-fed infants, members of the genus Bifidobacterium are commonly found in the GI tract of mammals. In humans, Bifidobacterium resides within the GI tract, from birth to old age. Disturbances in the microbiota are linked to an ever-growing number of immune-linked disease states including IBD, atopic allergy, arthritis, and obesity. Therefore, there is a significant interest in treating these diseases through microbial or "probiotic" supplementation of patients, including Bifidobacterium. Data from mouse models and clinical trials indicate that Bifidobacterium may have beneficial effects for treating and preventing immune-linked diseases, including gut-associated and systemic conditions. Bifidobacterium have been commercially exploited as probiotic agents due to their associated health benefits and GRAS; Generally Recognised As Safe status.... Read More | Alistipes is a relatively new genus of bacteria isolated primarily from medical clinical samples, although at a low rate compared to other genus members of the Bacteroidetes phylum, which are highly relevant in dysbiosis and disease. | iNeu™ human keratinocytes are derived from human dermal fibroblasts, using a feeder-free, serum-free, genetic-free, virus-free induced pluripotent stem cell (iPSC) line, and have fully defined proprietary induction and maturation conditions. iNeu™ cells can be cultured in a monolayer andiNeu™ human keratinocytes are derived from human dermal fibroblasts, using a feeder-free, serum-free, genetic-free, virus-free induced pluripotent stem cell (iPSC) line, and have fully defined proprietary induction and maturation conditions. iNeu™ cells can be cultured in a monolayer and can express different biomarkers, such as Cytokeratin-18. iNeu™ can be used under mature conditions, co-culture conditions (used with fibroblasts, melanocytes or other epidermal subtypes), and short-term functional characterization studies.... Read More | Creative Biolabs Human iPSC-Sensory Neuron Progenitors are derived from integration-free iPSCs and have been differentiated to neurons using small molecules. We offer a fully optimized cell culture system including tailored Sensory Maintenance Medium and coating reagents to promote the viability andCreative Biolabs Human iPSC-Sensory Neuron Progenitors are derived from integration-free iPSCs and have been differentiated to neurons using small molecules. We offer a fully optimized cell culture system including tailored Sensory Maintenance Medium and coating reagents to promote the viability and maturation of sensory neurons for endpoint assays on glass or plastic.
Our iPSC-derived sensory neurons express several voltage-gated sodium ion channels and transient receptor potential (TRP) ion channels that play a key role in nociception. These include sodium ion channels Nav1.7 and the DRG-specific, TTX-resistant channels, Nav1.8 and Nav1.9 as well as the temperature-sensitive, TRPV1 and TRPM8, and TRPA1, a sensor of pungency, bitterness and cold.
Creative Biolabs iPSC-Derived Sensory Neuron Progenitors are available in large batch sizes for reliable and consistent results in high-throughput screening assays. The cells are also suitable for investigating disorders of the peripheral nervous system and chronic pain as well as drug targets for pain relief.... Read More | The product SIRGT02109WQ-2F is a type of small interfering RNA (siRNA) that targets AP2A1 gene and regulates the expression of gene. The siRNA interferes with the expression of AP2A1 gene with complementary nucleotide sequences by degrading mRNA after transcription, preventing translation. The siRNAThe product SIRGT02109WQ-2F is a type of small interfering RNA (siRNA) that targets AP2A1 gene and regulates the expression of gene. The siRNA interferes with the expression of AP2A1 gene with complementary nucleotide sequences by degrading mRNA after transcription, preventing translation. The siRNA is designed with 2_-deoxy-2_-fluoro (2'-F) modification to provide increased stability, increased specificity and reduced immunogenicity. It has potential applications in RNA interference (RNAi) and gene therapy development.... Read More |