| Description | The product SIRGT52905WQ-2F is a type of small interfering RNA (siRNA) that targets ADSSL1 gene and regulates the expression of gene. The siRNA interferes with the expression of ADSSL1 gene with complementary nucleotide sequences by degrading mRNA after transcription, preventing translation. The The product SIRGT52905WQ-2F is a type of small interfering RNA (siRNA) that targets ADSSL1 gene and regulates the expression of gene. The siRNA interferes with the expression of ADSSL1 gene with complementary nucleotide sequences by degrading mRNA after transcription, preventing translation. The siRNA is designed with 2_-deoxy-2_-fluoro (2'-F) modification to provide increased stability, increased specificity and reduced immunogenicity. It has potential applications in RNA interference (RNAi) and gene therapy development.... Read More | Creative Biolabs Human iPSC-Sensory Neuron Progenitors are derived from integration-free iPSCs and have been differentiated to neurons using small molecules. We offer a fully optimized cell culture system including tailored Sensory Maintenance Medium and coating reagents to promote the viability andCreative Biolabs Human iPSC-Sensory Neuron Progenitors are derived from integration-free iPSCs and have been differentiated to neurons using small molecules. We offer a fully optimized cell culture system including tailored Sensory Maintenance Medium and coating reagents to promote the viability and maturation of sensory neurons for endpoint assays on glass or plastic.
Our iPSC-derived sensory neurons express several voltage-gated sodium ion channels and transient receptor potential (TRP) ion channels that play a key role in nociception. These include sodium ion channels Nav1.7 and the DRG-specific, TTX-resistant channels, Nav1.8 and Nav1.9 as well as the temperature-sensitive, TRPV1 and TRPM8, and TRPA1, a sensor of pungency, bitterness and cold.
Creative Biolabs iPSC-Derived Sensory Neuron Progenitors are available in large batch sizes for reliable and consistent results in high-throughput screening assays. The cells are also suitable for investigating disorders of the peripheral nervous system and chronic pain as well as drug targets for pain relief.... Read More | iNeuMito™ biosensor is a mitochondrial calcium flux sensor. These cells are engineered to express iNeuMito™ biosensor, which has been developed to use a highly sensitive fluorescence-based biosensor as a reporter gene to monitor mitochondrial calcium flux and cytotoxicity. Excitation = iNeuMito™ biosensor is a mitochondrial calcium flux sensor. These cells are engineered to express iNeuMito™ biosensor, which has been developed to use a highly sensitive fluorescence-based biosensor as a reporter gene to monitor mitochondrial calcium flux and cytotoxicity. Excitation = 610nm; emission = 625nm. The iNeuMito™ biosensor is introduced into the cell using a proprietary magnetic liposome-mediated method and expressed in the mitochondria (using a marker protein such as COX IV).
iNeuATP™, a fluorescent biosensor, has also been custom incorporated into the human iNeuRapid™ cell line. With iNeuATP™, biosensor assays provide fast kinetics (resolution in seconds) when measuring real-time cellular ATP metabolism and cytotoxicity. The analysis of cellular oxidative phosphorylation directly reflects the health and function of mitochondria. Excitation = 535nm; emission = 550nm.
Starting Materials: immortalized human cell line.... Read More | Creative Biolabs offers a range of recombinant cell lines for Immunotherapy discovery and development. | Lactobacillus species are normal flora of the human mouth, gastrointestinal tract, and female genital tract, where they produce lactic acid and competitively inhibit pathogenic organisms. Lactobacillus are small, slender, nonmotile, Gram-positive bacilli in chains. Immature colonies appear smooth, Lactobacillus species are normal flora of the human mouth, gastrointestinal tract, and female genital tract, where they produce lactic acid and competitively inhibit pathogenic organisms. Lactobacillus are small, slender, nonmotile, Gram-positive bacilli in chains. Immature colonies appear smooth, convex, and translucent. Some species of Lactobacillus used commonly as probiotics. They are most commonly used for diarrhea, including infectious diarrhea and diarrhea in people taking antibiotics. Some people also use lactobacillus for general digestion problems, irritable bowel syndrome; IBS, colic in infants, and many other conditions that involve the stomach and bowel.... Read More |