| Quantity | 20 nmol, 50 nmol, 100 nmol, 200 nmol | ~0.6x10^6 cells per 1ml of freezing medium (vial) | 1.5 million cells & Neural Plating-XF Medium | Inquire | Inquire |
| Description | The product SIRGT10901WQ is a type of small interfering RNA (siRNA) that targets MYC gene and regulates the expression of gene. The siRNA interferes with the expression of MYC gene with complementary nucleotide sequences by degrading mRNA after transcription, preventing translation. It has potentialThe product SIRGT10901WQ is a type of small interfering RNA (siRNA) that targets MYC gene and regulates the expression of gene. The siRNA interferes with the expression of MYC gene with complementary nucleotide sequences by degrading mRNA after transcription, preventing translation. It has potential applications in RNA interference (RNAi) and gene therapy development.... Read More | iNeu™ human dopaminergic neurons are derived from human dermal cells using a non-integrated induced pluripotent stem cell (iPSC) line under fully defined proprietary induction and maturation conditions. iNeu™ cells are plated in a monolayer when cultured, are branched, and express iNeu™ human dopaminergic neurons are derived from human dermal cells using a non-integrated induced pluripotent stem cell (iPSC) line under fully defined proprietary induction and maturation conditions. iNeu™ cells are plated in a monolayer when cultured, are branched, and express biomarkers such as beta3-Tuj (neurons), tyrosine hydroxylase (TH) and dopamine transporter (DAT). iNeu™ can be used under mature conditions, co-culture conditions (used with astrocytes or other neuronal subtypes), and short-term functional characterization studies.... Read More | Human iPSC-Derived Neural Stem Cells that have been genetically edited using CRISPR-Cas9 technology to introduce the P301L mutation (CCG>CTG) into the MAPT gene. This line is homozygous for the P301L mutation so both alleles contain the mutation. Click on the product images to see the data and Human iPSC-Derived Neural Stem Cells that have been genetically edited using CRISPR-Cas9 technology to introduce the P301L mutation (CCG>CTG) into the MAPT gene. This line is homozygous for the P301L mutation so both alleles contain the mutation. Click on the product images to see the data and further details.
The P301L mutation MAPT has been implicated in frontotemporal dementia and parkinsonism (Dumanchin et al., 1998). The mutation affects only the 4R isoforms of MAPT since the exon containing the mutation is spliced out of 3R isoforms (Hutton et al., 1998). Aggregated MAPT/tau protein in affected patients consisted mainly of the 4R isoform (Hutton et al., 1998). The P301L mutation promotes aggregation of MAPT/tau protein into ordered paired helical filaments and beta sheet formation in vitro (von Bergen et al., 2001).... Read More | Oxalobacter is a genus of bacteria in the Oxalobacteraceae family. The species are chemoorganotrophs and strictly anaerobic. They are found in rumens of animals such as cattle and in feces of other animals and humans. Some are marine and some have been isolated from fresh water. | Rhesus monkey is widely used in medical and biological research on human and animal related diseases even space travel due to its closeness to the human anatomically and physiologically. This product is isolated from Rhesus monkeys Vein Tissue. The sample is negative for Herpes-B Virus, as well as Rhesus monkey is widely used in medical and biological research on human and animal related diseases even space travel due to its closeness to the human anatomically and physiologically. This product is isolated from Rhesus monkeys Vein Tissue. The sample is negative for Herpes-B Virus, as well as SRV, SIV, STLV-1, and can be used for a variety of tests and assays such as PCR, Western blot, immunoprecipitation, immunofluorescent flow cytometry.... Read More |