| Description | Neural stem cells (NSC) are neural progenitor cells that can differentiate into different types of cells in the nervous system under certain conditions. Taking advantage of their continued reproduction, NSC has great potential for research in neurogenesis, neurodegenerative diseases, and clinical Neural stem cells (NSC) are neural progenitor cells that can differentiate into different types of cells in the nervous system under certain conditions. Taking advantage of their continued reproduction, NSC has great potential for research in neurogenesis, neurodegenerative diseases, and clinical transplantation applications. NeuroShop's human neural stem cell line is derived from human-induced pluripotent stem cells, which are produced from adult skin fibroblasts using a unique, non-footprint free iPSC reprogramming method. When cultured in a medium containing bFGF and EGF, these cells can normally proliferate without differentiation into neuronal cells.
Main features
Derived from human iPS cells without footprints
Homogeneous population
Under certain conditions, it can differentiate into more than 90% of neurons... Read More | Creative Biolabs' Neuropathy Frozen Tissue Panels are designed for the study of Alzheimer's disease, Parkinson's disease, dementia, multiple sclerosis, progressive supranuclear palsy (PSP) and depression. | Human iPSC-Derived Neural Stem Cells that have been genetically edited using CRISPR-Cas9 technology to introduce the P301L mutation (CCG>CTG) into the MAPT gene. This line is homozygous for the P301L mutation so both alleles contain the mutation. Click on the product images to see the data and Human iPSC-Derived Neural Stem Cells that have been genetically edited using CRISPR-Cas9 technology to introduce the P301L mutation (CCG>CTG) into the MAPT gene. This line is homozygous for the P301L mutation so both alleles contain the mutation. Click on the product images to see the data and further details.
The P301L mutation MAPT has been implicated in frontotemporal dementia and parkinsonism (Dumanchin et al., 1998). The mutation affects only the 4R isoforms of MAPT since the exon containing the mutation is spliced out of 3R isoforms (Hutton et al., 1998). Aggregated MAPT/tau protein in affected patients consisted mainly of the 4R isoform (Hutton et al., 1998). The P301L mutation promotes aggregation of MAPT/tau protein into ordered paired helical filaments and beta sheet formation in vitro (von Bergen et al., 2001).... Read More | This product GTTS-WQ5797MR is a type of mRNA having 30 nt poly(A) tail and modified with Cap 0 & 5-Methyl-CTP & Pseudo-UTP. It ecodes the monoclonal antibody that targets CD40 gene. The antibody can be applied in Kidney transplant rejection, Psoriasis, Myasthenia Gravis (MG) research. | The product SIRGT63524WQ-2MOE is a type of small interfering RNA (siRNA) that targets PIKFYVE gene and regulates the expression of gene. The siRNA interferes with the expression of PIKFYVE gene with complementary nucleotide sequences by degrading mRNA after transcription, preventing translation. TheThe product SIRGT63524WQ-2MOE is a type of small interfering RNA (siRNA) that targets PIKFYVE gene and regulates the expression of gene. The siRNA interferes with the expression of PIKFYVE gene with complementary nucleotide sequences by degrading mRNA after transcription, preventing translation. The siRNA is systematically modified with the synthetic RNA-like high affinity nucleotide analogue, Locked Nucleic Acid (LNA), to improve its bio-stability, specificity and efficiency. It has potential applications in RNA interference (RNAi) and gene therapy development.... Read More |