| Description | Researchers at the Creative Biolabs have developed BALB/c Mouse Splenocytes that allows for study in numerous research areas, such as immunology, oncology. The cells can be used for a wide variety of safety assessment and functional assays. | Cynomolgus monkey is widely used in medical experiments, especially those associated with neuroscience and disease. This product is isolated from Cynomolgus monkey stomach tissue. Cells are negative for bacteria, yeast, fungi, mycoplasma, and can be used for a variety of tests and assays such as Cynomolgus monkey is widely used in medical experiments, especially those associated with neuroscience and disease. This product is isolated from Cynomolgus monkey stomach tissue. Cells are negative for bacteria, yeast, fungi, mycoplasma, and can be used for a variety of tests and assays such as cell-cell interaction, adhesion, migration, PCR, Western blot, immunoprecipitation, immunofluorescent staining, immunofluorescent flow cytometry, or generating cell derivatives for desired research applications.... Read More | The Creative Biolabs footprint-free human iPS (induced pluripotent stem) cell line carrying the APOE-ε2 variant was derived from Creative Biolabs' syngeneic iPSC line (catalog number NCL-2103-P91) through advanced genome editing tools. The results confirmed that iPS46 is a homozygous line with The Creative Biolabs footprint-free human iPS (induced pluripotent stem) cell line carrying the APOE-ε2 variant was derived from Creative Biolabs' syngeneic iPSC line (catalog number NCL-2103-P91) through advanced genome editing tools. The results confirmed that iPS46 is a homozygous line with stable homozygous transformation with Cys112 (TGC) from Arg112 (CGC) and Cys158 (TGC) from Arg158 (CGC) in APOE gene. The morphology of this human iPS cell line is similar to Human ES cells are the same. They also express pluripotency markers TRA-1-60, SSEA-3 and Oct4, and show strong endogenous alkaline phosphatase activity.
feature: Derived from a single iPSC clone Have the same genetic background Ready-made-simply thaw the cells and inoculate them in a serum-free, feeder-free culture No genetic modification and no virus Shows the expression of pluripotency markers and endogenous alkaline phosphatase activity... Read More | Human iPSC-Derived Neural Stem Cells that have been genetically edited using CRISPR-Cas9 technology to introduce the P301L mutation (CCG>CTG) into the MAPT gene. This line is homozygous for the P301L mutation so both alleles contain the mutation. Click on the product images to see the data and Human iPSC-Derived Neural Stem Cells that have been genetically edited using CRISPR-Cas9 technology to introduce the P301L mutation (CCG>CTG) into the MAPT gene. This line is homozygous for the P301L mutation so both alleles contain the mutation. Click on the product images to see the data and further details.
The P301L mutation MAPT has been implicated in frontotemporal dementia and parkinsonism (Dumanchin et al., 1998). The mutation affects only the 4R isoforms of MAPT since the exon containing the mutation is spliced out of 3R isoforms (Hutton et al., 1998). Aggregated MAPT/tau protein in affected patients consisted mainly of the 4R isoform (Hutton et al., 1998). The P301L mutation promotes aggregation of MAPT/tau protein into ordered paired helical filaments and beta sheet formation in vitro (von Bergen et al., 2001).... Read More | The product SIRGT25964WQ is a type of small interfering RNA (siRNA) that targets NRXN3 gene and regulates the expression of gene. The siRNA interferes with the expression of NRXN3 gene with complementary nucleotide sequences by degrading mRNA after transcription, preventing translation. It has The product SIRGT25964WQ is a type of small interfering RNA (siRNA) that targets NRXN3 gene and regulates the expression of gene. The siRNA interferes with the expression of NRXN3 gene with complementary nucleotide sequences by degrading mRNA after transcription, preventing translation. It has potential applications in RNA interference (RNAi) and gene therapy development.... Read More |