| Description | Rat midbrain neurons (RMbN) are obtained from the midbrain of normal embryonic rats (the 15th day of pregnancy) by a standardized method. When cultured under the recommended conditions, RMbN forms a tree shape and complex formation within one week. The neurite network. RMBN is positive for βIIIRat midbrain neurons (RMbN) are obtained from the midbrain of normal embryonic rats (the 15th day of pregnancy) by a standardized method. When cultured under the recommended conditions, RMbN forms a tree shape and complex formation within one week. The neurite network. RMBN is positive for βIII-tubulin. The midbrain is a small part of the brain, but plays an important role in the visual and auditory systems, motor control, alertness, sleep/wake and temperature regulation. It contains the substantia nigra, which is a dark area with a large number of dopaminergic neurons, which is closely related to motivation and habits. Midbrain atrophy and diseases seen in diseases such as Parkinson's disease, familial amyotrophic lateral sclerosis, and progressive supranuclear palsy can affect balance, gait, and muscle control. Studying midbrain neurons under those disease conditions will enable people to better understand disease mechanisms, physiopathology, and progress in drug development and treatment. The culture of midbrain neurons can be used in a variety of experiments, including toxicity tests, immunostaining, live cell imaging, co-culture, electrophysiology, etc.... Read More | Creative Biolabs Human iPSC-Sensory Neuron Progenitors are derived from integration-free iPSCs and have been differentiated to neurons using small molecules. We offer a fully optimized cell culture system including tailored Sensory Maintenance Medium and coating reagents to promote the viability andCreative Biolabs Human iPSC-Sensory Neuron Progenitors are derived from integration-free iPSCs and have been differentiated to neurons using small molecules. We offer a fully optimized cell culture system including tailored Sensory Maintenance Medium and coating reagents to promote the viability and maturation of sensory neurons for endpoint assays on glass or plastic.
Our iPSC-derived sensory neurons express several voltage-gated sodium ion channels and transient receptor potential (TRP) ion channels that play a key role in nociception. These include sodium ion channels Nav1.7 and the DRG-specific, TTX-resistant channels, Nav1.8 and Nav1.9 as well as the temperature-sensitive, TRPV1 and TRPM8, and TRPA1, a sensor of pungency, bitterness and cold.
Creative Biolabs iPSC-Derived Sensory Neuron Progenitors are available in large batch sizes for reliable and consistent results in high-throughput screening assays. The cells are also suitable for investigating disorders of the peripheral nervous system and chronic pain as well as drug targets for pain relief.... Read More | Creative Biolabs offers a range of recombinant cell lines for Immunotherapy discovery and development. | The product SIRGT77459WQ-2F is a type of small interfering RNA (siRNA) that targets MAT2B gene and regulates the expression gene. The siRNA interferes with the expression MAT2B gene with complementary nucleotide sequences by degrading mRNA after transcription, preventing translation. The siRNA is The product SIRGT77459WQ-2F is a type of small interfering RNA (siRNA) that targets MAT2B gene and regulates the expression gene. The siRNA interferes with the expression MAT2B gene with complementary nucleotide sequences by degrading mRNA after transcription, preventing translation. The siRNA is designed with 2_-deoxy-2_-fluoro (2'-F) modification to provide increased stability, increased specificity and reduced immunogenicity. It has potential applications in RNA interference (RNAi) and gene therapy development.... Read More | The product SIRGT70081WQ is a type of small interfering RNA (siRNA) that targets NSL1 gene and regulates the expression of gene. The siRNA interferes with the expression of NSL1 gene with complementary nucleotide sequences by degrading mRNA after transcription, preventing translation. It has The product SIRGT70081WQ is a type of small interfering RNA (siRNA) that targets NSL1 gene and regulates the expression of gene. The siRNA interferes with the expression of NSL1 gene with complementary nucleotide sequences by degrading mRNA after transcription, preventing translation. It has potential applications in RNA interference (RNAi) and gene therapy development.... Read More |