MALDI TOF mass spectrometers (matrix-assisted laser desorption/ionization/time-of-flight) are amongst the most popular mass spec instruments in biology. They combine two technologies, the “soft” MALDI ionization source and the TOF mass analyzer. The latter measures an ion’s mass-to-charge ratio (m/z) by measuring the time it takes to reach a detector. The former volatilizes and ionizes those molecules using a laser, a target, and an organic compound called a matrix. In MALDI, a sample (for instance, a collection of tryptic peptides) is mixed with matrix, spotted and dried (crystallized) on the surface of a metal target plate. Upon irradiation with laser light, the matrix absorbs the energy and converts it to heat, which then causes the sample to ionize and explode off the plate into the mass analyzer. MALDI TOF mass spectrometers come in two basic flavors, MALDI TOF MS and MALDI TOF/TOF MS; the latter enables tandem MS (MS/MS) studies.
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| Company | Shimadzu | Shimadzu | Shimadzu |
| Item | MALDI-8030 EasyCare Benchtop Linear Dual Polarity MALDI-TOF Mass Spectrometer | MALDI-8020 EasyCare Benchtop Linear MALDI-TOF Mass Spectrometer | MALDImini-1 Compact MALDI Digital Ion Trap Mass Spectrometer |
| Catalog Number | MALDI-8030 | MALDI-8020 | MALDImini-1 |
| Price | | | |
| Ionization Method(s) | MALDI | MALDI | MALDI ion source |
| Mass Analyzer | TOF | TOF | Digital Ion Trap (DIT) |
| Resolution | >5000 FWHM – ACTH 18-39 (m/z 2465) | > 5000 FWHM – ACTH 18-39 (m/z 2465) | Inquire |
| Mass Range | m/z 1 - 500,000 | m/z 1 - 500,000 | Inquire |
| Description | The MALDI-8030 is a dual-polarity, benchtop linear MALDI-TOF mass spectrometer that delivers outstanding performance in a compact footprint, making it an ideal choice for today’s increasingly demanding laboratories.
The dual-polarity ion source of the MALDI-8030 allows the flexibility to analyze The MALDI-8030 is a dual-polarity, benchtop linear MALDI-TOF mass spectrometer that delivers outstanding performance in a compact footprint, making it an ideal choice for today’s increasingly demanding laboratories.
The dual-polarity ion source of the MALDI-8030 allows the flexibility to analyze a wide range of samples including proteins, peptides, oligonucleotides, lipids, glycans, polymers and small molecules. Its enhanced sample throughput, ease-of-use, low maintenance and small footprint make it ideal for all laboratories. Moreover, its quiet operation at <55 dB expands use beyond the conventional laboratory setting.
Key features include:
- Dual mode (positive/negative ion) MALDI-TOF; supports MS imaging at a benchtop scale
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200 Hz solid-state laser, 355 nm, for class-leading two billion shots per lifetime
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Load-lock chamber for fast sample introduction
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UV laser-based source cleaning (patented) – enables seamless self-cleaning of the ion optics, without breaking vacuum and requiring the removal of the ion optics
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Patented WideBore™ ion optics technology – significantly reduces contamination from the desorbed MALDI sample
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Easy routine maintenance of the ion optics
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Quiet operation (<55 dB)
In addition, the integrated barcode reader, when used with FlexiMass™-DS slides, is compatible with AuraSolution™ and SampleStation™ automated analysis software and can provide seamless tracking to reduce misidentification errors.
Tailored MALDI Solutions acquisition software features data security for regulatory compliance facilitated with password-controlled user login, encrypted data and user traceability.... Read More | Through innovative instrument design, the space-saving linear MALDI-8020 achieves performance specifications similar to those of larger, more expensive MALDI-TOF models but in a significantly smaller footprint. The MALDI-8020 improves laboratory efficiency and accelerates analysis through a newly Through innovative instrument design, the space-saving linear MALDI-8020 achieves performance specifications similar to those of larger, more expensive MALDI-TOF models but in a significantly smaller footprint. The MALDI-8020 improves laboratory efficiency and accelerates analysis through a newly designed load-lock system for rapid sample target introduction and a solid-state laser for fast data acquisition speeds. Using linear time of flight, this compact MALDI-TOF system enables low-level detection of proteins, peptides and polymers, among other analytes. In addition, it easily accommodates standard laboratory workflows such as peptide mass finger printing for simple protein ID confirmation, in-source decay (ISD) and polymer distribution analysis.
Features: - Compact benchtop design
- Rapid loading and acquisition
- Automated source cleaning
- Integrated barcode scanner
The MALDI-8020, operated by MALDI Solutions software, is ideally suited for pharmaceutical QC labs as well as academic and industrial labs with limited laboratory space. With the addition of the MALDI-TOF Imaging Starter Kit, MS imaging on a benchtop system is now possible. MALDI Solutions offers intuitive, yet secure, operation, including security, audit trails and user management, to help meet 21 CFR Part 11 compliance. Additionally, the simple and intuitive user interface makes this an ideal teaching tool.... Read More | Inquire |
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