MALDI TOF mass spectrometers (matrix-assisted laser desorption/ionization/time-of-flight) are amongst the most popular mass spec instruments in biology. They combine two technologies, the “soft” MALDI ionization source and the TOF mass analyzer. The latter measures an ion’s mass-to-charge ratio (m/z) by measuring the time it takes to reach a detector. The former volatilizes and ionizes those molecules using a laser, a target, and an organic compound called a matrix. In MALDI, a sample (for instance, a collection of tryptic peptides) is mixed with matrix, spotted and dried (crystallized) on the surface of a metal target plate. Upon irradiation with laser light, the matrix absorbs the energy and converts it to heat, which then causes the sample to ionize and explode off the plate into the mass analyzer. MALDI TOF mass spectrometers come in two basic flavors, MALDI TOF MS and MALDI TOF/TOF MS; the latter enables tandem MS (MS/MS) studies.
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| Company | Shimadzu | Shimadzu | Shimadzu |
| Item | MALDI-8030 EasyCare Benchtop Linear Dual Polarity MALDI-TOF Mass Spectrometer | AXIMA-iD Plus Microorganism Analysis | iMScope QT Imaging Mass Microscope |
| Citations | | | |
| Catalog Number | MALDI-8030 | AXIMA-iD Plus | iMScope QT |
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| Ionization Method(s) | MALDI | MALDI | Atmospheric Pressure MALDI (AP-MALDI) |
| Mass Analyzer | TOF | MALDI-TOF MS | Q-TOF |
| Resolution | >5000 FWHM – ACTH 18-39 (m/z 2465) | Inquire | Inquire |
| Scanning Speed | Inquire | Inquire | Inquire |
| Mass Range | m/z 1 - 500,000 | Varies based on MALDI-TOF system used | Inquire |
| Description | The MALDI-8030 is a dual-polarity, benchtop linear MALDI-TOF mass spectrometer that delivers outstanding performance in a compact footprint, making it an ideal choice for today’s increasingly demanding laboratories.
The dual-polarity ion source of the MALDI-8030 allows the flexibility to analyze The MALDI-8030 is a dual-polarity, benchtop linear MALDI-TOF mass spectrometer that delivers outstanding performance in a compact footprint, making it an ideal choice for today’s increasingly demanding laboratories.
The dual-polarity ion source of the MALDI-8030 allows the flexibility to analyze a wide range of samples including proteins, peptides, oligonucleotides, lipids, glycans, polymers and small molecules. Its enhanced sample throughput, ease-of-use, low maintenance and small footprint make it ideal for all laboratories. Moreover, its quiet operation at <55 dB expands use beyond the conventional laboratory setting.
Key features include:
- Dual mode (positive/negative ion) MALDI-TOF; supports MS imaging at a benchtop scale
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200 Hz solid-state laser, 355 nm, for class-leading two billion shots per lifetime
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Load-lock chamber for fast sample introduction
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UV laser-based source cleaning (patented) – enables seamless self-cleaning of the ion optics, without breaking vacuum and requiring the removal of the ion optics
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Patented WideBore™ ion optics technology – significantly reduces contamination from the desorbed MALDI sample
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Easy routine maintenance of the ion optics
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Quiet operation (<55 dB)
In addition, the integrated barcode reader, when used with FlexiMass™-DS slides, is compatible with AuraSolution™ and SampleStation™ automated analysis software and can provide seamless tracking to reduce misidentification errors.
Tailored MALDI Solutions acquisition software features data security for regulatory compliance facilitated with password-controlled user login, encrypted data and user traceability.... Read More | Certain microorganisms can cause severe diseases and considerable damage, and need to be identified quickly and reliably. The easy-to-use AXIMA-iDPlus Microbial Identification System is the ideal tool to address these concerns. With AXIMA-iDPlus, cultured microorganisms can be directly applied to Certain microorganisms can cause severe diseases and considerable damage, and need to be identified quickly and reliably. The easy-to-use AXIMA-iDPlus Microbial Identification System is the ideal tool to address these concerns. With AXIMA-iDPlus, cultured microorganisms can be directly applied to the MALDI sample target and introduced to an AXIMA series MALDI-TOF mass spectrometer to revolutionize the daily routine in analytical and diagnostic laboratories.
Fast Response, Outstanding Recovery Rate
AXIMA-iDPlus can identify 380 clinical research samples within 5 hours in the high-throughput mode, less than one minute per sample. The results appear in a comprehensible spreadsheet format, exportable to common data processing software.
Gram-positive and gram-negative bacteria, yeast, fungi and spores are identified based on their characteristic MALDI-TOF MS fingerprints with up to 98% recovery rate down to sub-species level.
Substitutes Biochemical Standard Methods
No pre-selection of analytical methods is required; hands-on time is reduced and costs are cut dramatically.
Wide Range of Applications
AXIMA-iDPlus covers a wide range of applications in a number of industries, including diagnostics, pharmaceuticals, healthcare and food. Examples include:
- Diagnosis of human and veterinarian infectious pathogens
- Drug discovery process
- Culture collections
- Food and beverage manufacturing processes
Complementary Method
Designed for medium to high-throughput identification, AXIMA-iDPlus can be easily integrated into automated laboratory environments and any LIMS.... Read More | Inquire |
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