Maldi TOF Mass Spectrometer (MALDI TOF MS)

MALDI TOF mass spectrometers (matrix-assisted laser desorption/ionization/time-of-flight) are amongst the most popular mass spec instruments in biology. They combine two technologies, the “soft” MALDI ionization source and the TOF mass analyzer. The latter measures an ion’s mass-to-charge ratio (m/z) by measuring the time it takes to reach a detector. The former volatilizes and ionizes those molecules using a laser, a target, and an organic compound called a matrix. In MALDI, a sample (for instance, a collection of tryptic peptides) is mixed with matrix, spotted and dried (crystallized) on the surface of a metal target plate. Upon irradiation with laser light, the matrix absorbs the energy and converts it to heat, which then causes the sample to ionize and explode off the plate into the mass analyzer. MALDI TOF mass spectrometers come in two basic flavors, MALDI TOF MS and MALDI TOF/TOF MS; the latter enables tandem MS (MS/MS) studies.
CompanyShimadzuShimadzuShimadzuShimadzuShimadzu
ItemAxima Confidence MALDI TOF Mass SpectrometerAxima Assurance MALDI Time of Flight Mass SpectrometerBenchtop MALDI Imaging KitMALDI-8020 EasyCare Benchtop Linear MALDI-TOF Mass SpectrometerMegaTOF Megadalton MALDI Mass Spectrometer
Citations
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Figures
Catalog NumberAxima ConfidenceAXIMA AssuranceBenchtop MALDI ImagingMALDI-8020MegaTOF
Price
Ionization Method(s)MALDIMALDIInquireMALDIMALDI
Mass AnalyzerTOFTOFInquireTOFTOF
Resolution5000 FWHM in linear mode; 15000 FWHM in reflectron mode>5000 FWHMInquire> 5000 FWHM – ACTH 18-39 (m/z 2465)180 to 200 kDa
Scanning SpeedInquireInquireFastMS feature - with the 200 Hz laser, fast sample slide introduction ( <3 min), and quick sample stage – provides the speed to attain up to 15 pixels per second (lipid imaging acquisition (100 to 1200 m/z) at 50 µm spacing using an the accumulation rate of 10 shots/profile).Inquire15 sec/position
Mass Range1 kDa to 500 kDa1 kDa to 500 kDaInquirem/z 1 - 500,0000.01 to 1.5 Mda
Description

An affordable, robust option for routine sample analysis performed manually or automatically, the AXIMA Confidence offers reliable mass information and MS/MS-derived structural detail. A linear mode enables outstanding levels of analysis of high-molecular weight samples while the reflectron mode,

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An affordable, robust option for laboratories requiring routine manual or automated analysis of a wide variety of sample classes, the AXIMA Assurance provides high-quality, rapid MALDI mass spectra and an array of software tools for data processing and reporting. Incorporating a variable repetition

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The Benchtop MALDI-TOF Imaging Kit is ideal for users starting out in the world of biomolecular imaging. Used in conjunction with the compact benchtop MALDI-TOF 8020/8030 systems, it provides a welcoming platform by combining the ease of MALDI analysis with extremely intuitive software in an all-... Read MoreThrough innovative instrument design, the space-saving linear MALDI-8020 achieves performance specifications similar to those of larger, more expensive MALDI-TOF models but in a significantly smaller footprint. The MALDI-8020 improves laboratory efficiency and accelerates analysis through a newly ... Read MoreThe MegaTOF has been developed by optimizing the integration of a high-performance Shimadzu linear MALDI TOF mass spectrometer with a CovalX high-mass system, allowing outstanding detection of macromolecules up to 1,500 kDa.

Features
  • Ultrahigh sensitivity
  • Detects macromolecules up to 1,500,000 Da
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