MALDI TOF mass spectrometers (matrix-assisted laser desorption/ionization/time-of-flight) are amongst the most popular mass spec instruments in biology. They combine two technologies, the “soft” MALDI ionization source and the TOF mass analyzer. The latter measures an ion’s mass-to-charge ratio (m/z) by measuring the time it takes to reach a detector. The former volatilizes and ionizes those molecules using a laser, a target, and an organic compound called a matrix. In MALDI, a sample (for instance, a collection of tryptic peptides) is mixed with matrix, spotted and dried (crystallized) on the surface of a metal target plate. Upon irradiation with laser light, the matrix absorbs the energy and converts it to heat, which then causes the sample to ionize and explode off the plate into the mass analyzer. MALDI TOF mass spectrometers come in two basic flavors, MALDI TOF MS and MALDI TOF/TOF MS; the latter enables tandem MS (MS/MS) studies.
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| Company | Shimadzu | Shimadzu | Shimadzu |
| Item | AXIMA-iD Plus Microorganism Analysis | iMScope QT Imaging Mass Microscope | MALDI-8020 EasyCare Benchtop Linear MALDI-TOF Mass Spectrometer |
| Citations | | | |
| Catalog Number | AXIMA-iD Plus | iMScope QT | MALDI-8020 |
| Price | | | |
| Ionization Method(s) | MALDI | Atmospheric Pressure MALDI (AP-MALDI) | MALDI |
| Mass Analyzer | MALDI-TOF MS | Q-TOF | TOF |
| Resolution | Inquire | Inquire | > 5000 FWHM – ACTH 18-39 (m/z 2465) |
| Scanning Speed | Inquire | Inquire | Inquire |
| Mass Range | Varies based on MALDI-TOF system used | Inquire | m/z 1 - 500,000 |
| Description | Certain microorganisms can cause severe diseases and considerable damage, and need to be identified quickly and reliably. The easy-to-use AXIMA-iDPlus Microbial Identification System is the ideal tool to address these concerns. With AXIMA-iDPlus, cultured microorganisms can be directly applied to Certain microorganisms can cause severe diseases and considerable damage, and need to be identified quickly and reliably. The easy-to-use AXIMA-iDPlus Microbial Identification System is the ideal tool to address these concerns. With AXIMA-iDPlus, cultured microorganisms can be directly applied to the MALDI sample target and introduced to an AXIMA series MALDI-TOF mass spectrometer to revolutionize the daily routine in analytical and diagnostic laboratories.
Fast Response, Outstanding Recovery Rate
AXIMA-iDPlus can identify 380 clinical research samples within 5 hours in the high-throughput mode, less than one minute per sample. The results appear in a comprehensible spreadsheet format, exportable to common data processing software.
Gram-positive and gram-negative bacteria, yeast, fungi and spores are identified based on their characteristic MALDI-TOF MS fingerprints with up to 98% recovery rate down to sub-species level.
Substitutes Biochemical Standard Methods
No pre-selection of analytical methods is required; hands-on time is reduced and costs are cut dramatically.
Wide Range of Applications
AXIMA-iDPlus covers a wide range of applications in a number of industries, including diagnostics, pharmaceuticals, healthcare and food. Examples include:
- Diagnosis of human and veterinarian infectious pathogens
- Drug discovery process
- Culture collections
- Food and beverage manufacturing processes
Complementary Method
Designed for medium to high-throughput identification, AXIMA-iDPlus can be easily integrated into automated laboratory environments and any LIMS.... Read More | Inquire | Through innovative instrument design, the space-saving linear MALDI-8020 achieves performance specifications similar to those of larger, more expensive MALDI-TOF models but in a significantly smaller footprint. The MALDI-8020 improves laboratory efficiency and accelerates analysis through a newly Through innovative instrument design, the space-saving linear MALDI-8020 achieves performance specifications similar to those of larger, more expensive MALDI-TOF models but in a significantly smaller footprint. The MALDI-8020 improves laboratory efficiency and accelerates analysis through a newly designed load-lock system for rapid sample target introduction and a solid-state laser for fast data acquisition speeds. Using linear time of flight, this compact MALDI-TOF system enables low-level detection of proteins, peptides and polymers, among other analytes. In addition, it easily accommodates standard laboratory workflows such as peptide mass finger printing for simple protein ID confirmation, in-source decay (ISD) and polymer distribution analysis.
Features: - Compact benchtop design
- Rapid loading and acquisition
- Automated source cleaning
- Integrated barcode scanner
The MALDI-8020, operated by MALDI Solutions software, is ideally suited for pharmaceutical QC labs as well as academic and industrial labs with limited laboratory space. With the addition of the MALDI-TOF Imaging Starter Kit, MS imaging on a benchtop system is now possible. MALDI Solutions offers intuitive, yet secure, operation, including security, audit trails and user management, to help meet 21 CFR Part 11 compliance. Additionally, the simple and intuitive user interface makes this an ideal teaching tool.... Read More |
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