Q-TOF mass spectrometers combine TOF and quadrupole instruments, a pairing that results in high mass accuracy for precursor and product ions, strong quantitation capability, and fragmentation experiment applicability. The Q-TOF MS uses a quadrupole (four parallel rods arranged in a square formation), a collision cell, and a time of flight unit to produce spectra. Lighter ions accelerate faster down the flight tube to the detector, thus determining the ions’ mass-to-charge ratios. Q-TOF MS systems have MS-MS capabilities and can be coupled to GC or LC systems. Ion sources include MALDI, ESI, APCI, and APPI. Speed and sensitivity are hallmarks of the quadrupole TOF MS, with detection reaching low-femtogram levels. Their speed and suitability for quantitative analysis make these hybrid instruments a popular choice for chemists building combinatorial libraries. They are also widely used in drug discovery, clinical research, forensic toxicology, food safety, and environmental screening.
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| Company | SCIEX | SCIEX | SCIEX | SCIEX |
| Item | ZenoTOF 7600 system | X500R QTOF system | ZenoTOF 7600+ system | ZenoTOF 8600 system |
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| Catalog Number | ZenoTOF 7600 | X500R QTOF | | |
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| Description | A powerful leap in proprietary innovation, this high-resolution accurate mass system combines the power of Zeno trap pulsing with EAD fragmentation technology (electron activated dissociation) to uncover structural information, previously inaccessible, and drive the limits of quantification A powerful leap in proprietary innovation, this high-resolution accurate mass system combines the power of Zeno trap pulsing with EAD fragmentation technology (electron activated dissociation) to uncover structural information, previously inaccessible, and drive the limits of quantification achievable with accurate mass.... Read More | Engineered for standard biotherapeutic characterization analyses, the X500B QTOF system is a true benchtop instrument, with streamlined processing to get to a consistent, accurate view of your biologic. It is optimized for intact mass analysis, subunit analysis as well as high-quality peptide Engineered for standard biotherapeutic characterization analyses, the X500B QTOF system is a true benchtop instrument, with streamlined processing to get to a consistent, accurate view of your biologic. It is optimized for intact mass analysis, subunit analysis as well as high-quality peptide mapping workflows.... Read More | Inquire | Inquire |
| Ionization Method(s) | APCI and ESI modes | Turbo V ion source with twin sprayer ESI probe
and twin sprayer APCI probe | TwinSpray, OptiFlow Turbo V (ESI, APCI) | OptiFlow Pro Ion Source (ESI, APCI) |
| Mass Analyzer | TOF | QTOF | Quadrupole Time-of-Flight (QTOF) with Zeno Trap + Scanning Quadrupole | Quadrupole Time-of-Flight (QTOF) with Zeno Trap |
| Mass Range | TOF: 40 kDa
Precursor Ion Selection: 5–2250 m/z | TOF: 40 kDa
Precursor Ion Selection: 5–2250 m/z | Inquire | Inquire |
| Scanning Speed | up to 25 Hz (25 spectra per second) | Up to 25 Hz (25 spectra per second) | Up to 858 Hz | Up to 858 Hz; quadrupole scanning up to 4,000 Da/s |
| Resolution | Equal to or greater than 42,000 (FWHM) measured on the [M+6H]6+ charge isotope cluster for bovine insulin at m/z 956 | Equal to or greater than 42,000 (FWHM) measured on the (M+6H)6+ charge isotope cluster for bovine insulin at m/z 956 | Inquire | Inquire |
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