Comprising two components, a liquid-phase separation system and a mass spectrometer, liquid chromatograph mass spectrometers (LC MS instruments) couple sample fractionation and analysis. The separation can be accomplished via standard liquid chromatography, HPLC, UPLC, or even nano-LC. Any liquid-phase separation will do, so long as its output can be directed into the mass analyzer (for instance, via an electrospray ionization source). The mass spectrometer is similarly flexible, ranging from the simplest single quadrupole to a Fourier transform ion cyclotron resonance instrument. Just remember, in a liquid chromatograph mass spectrometer the column flow is continuous, meaning the mass analyzer must be fast enough to thoroughly analyze one peak before the next one comes off the column. And, unlike with MALDI MS, once a peak is analyzed, it’s gone.
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PerkinElmer
- ESI, APCI
- Triple Quadrupole
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JASCO
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- 10,000 m/z units/sec (compatible with UHPLC)
- 0.5 to 0.7 m/z units (FWHM) at 1,000 m/z units/sec over entire acquisition range
SCIEX
- Electrospray Ionization
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- Up to 3 samples per second
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SCIEX
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SCIEX
- OptiFlow® Pro Ion Source
- Triple quadrupole
- 20,000 Da/s
- Up to 3100 for mass 922 in LIT mode 1000 Da/s (0.3 Da)
Tune to a peak width of 0.5 Da for TQ mode
SCIEX
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SCIEX
- Turbo V ion source with twin sprayer ESI probe
and twin sprayer APCI probe - QTOF
- Up to 25 Hz (25 spectra per second)
- Equal to or greater than 42,000 (FWHM) measured on the (M+6H)6+ charge isotope cluster for bovine insulin at m/z 956
SCIEX
- APCI and ESI modes
- TOF
- up to 25 Hz (25 spectra per second)
- Equal to or greater than 42,000 (FWHM) measured on the [M+6H]6+ charge isotope cluster for bovine insulin at m/z 956
Shimadzu
- ESI, APCI, Dual Ionization
- Single Quadrupole
- 15,000 u/sec
- R = 2 M
Shimadzu
- ESI, APCI, Dual Ionization
- Single Quadrupole
- 15,000 u/sec
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Shimadzu
- ESI, APCI, Dual Ionization
- Q1 & Q3 are molybdenum hyperbolic mass filters with pre-rods; Q1 includes post-rods
- 30,000 u/sec
- R < 0.7 u FWHM
Shimadzu
- ESI probe with focus electrodes
- Triple quadrupole
- Max. 30,000 u/sec (in all scan modes)
(0.1 u step: 300,000 data points/sec) - R < 0.7 u FWHM and adjustable to 0.5 u
Shimadzu
- ESI, APCI, Dual Ionization
- Q1 & Q3 are molybdenum hyperbolic mass filters with pre-rods; Q1 includes post-rods
- 30,000 u/sec
- R < 0.7 u FWHM
Shimadzu
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Shimadzu
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Thermo Fisher Scientific
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- UHMR Hybrid Quadrupole-Orbitrap™
- up to 12 Hz at resolution setting of 12,500 at m/z 400
- 200,000 at m/z 400
Thermo Fisher Scientific
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- 7500 to 480,000 (FWHM) at m/z 200
Thermo Fisher Scientific
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Thermo Fisher Scientific
- APCI, H-ESI
- Orbitrap
- Up to 12 Hz
- up to 140,000 FWHM
Thermo Fisher Scientific
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Thermo Fisher Scientific
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Thermo Fisher Scientific
- API, HESI
- Single quadrupole
- Up to 20,000 Da/sec.
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Thermo Fisher Scientific
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Thermo Fisher Scientific
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- OTMSn up to 40 Hz ITMSn up to 45 Hz
- 7500 to 500,000 (FWHM) at m/z 200
Thermo Fisher Scientific
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Thermo Fisher Scientific
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- 480,000 at m/z 195
Thermo Fisher Scientific
- HESI
- Orbitrap
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- 7500-500,000 (FWHM) at m/z 200
Thermo Fisher Scientific
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- 7500 to 500,000 (FWHM) at m/z 200
Thermo Fisher Scientific
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Thermo Fisher Scientific
- APCI, H-ESI
- Hybrid Quadrupole / Orbitrap
- Up to 12 Hz
- up to 280,000 FWHM
Thermo Fisher Scientific
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