| Description | Covering the complete range from micro (0.1 µL/min) to semi-micro (500 µL/min), Nexera Mikros allows operators to realize high sensitivity with the reliability and ruggedness of HPLC. A newly designed micro ESI source provides greater than ten times the sensitivity of standard UHPLC-MS Covering the complete range from micro (0.1 µL/min) to semi-micro (500 µL/min), Nexera Mikros allows operators to realize high sensitivity with the reliability and ruggedness of HPLC. A newly designed micro ESI source provides greater than ten times the sensitivity of standard UHPLC-MS systems, while the system’s UF-Link allows operators to correctly and easily connect any microflow column to ensure a zero-dead volume connection every time.
- Sensitivity gains of greater than 10X can be seen over conventional LCMS for assays of small molecules, peptides and proteins.
- Micro-ESI LCMS source designed for optimal sensitivity and ease of use. An X–Y adjustable stage and viewing camera allow for easy ESI spray needle adjustment
- Column oven mounted on the LCMS to minimize the volume between the exit of the column and the ESI needle.
- Proprietary UF-Link technology makes robust and correct connections of microflow columns a breeze
- Fast, accurate, reproducible autosampler with extremely low carry-over; injection volume ranges from 0.1 to 50 µL
- Consistent peak retention times and peak areas
... Read More | The LCMS-2050 single quadrupole mass spectrometer combines the user-friendliness of an LC detector with the excellent performance of MS to provide a complete package of easy-to-use high-level performance and compactness. To make it accessible to all users, the system is enhanced with technology and The LCMS-2050 single quadrupole mass spectrometer combines the user-friendliness of an LC detector with the excellent performance of MS to provide a complete package of easy-to-use high-level performance and compactness. To make it accessible to all users, the system is enhanced with technology and functions to ensure that even technicians unfamiliar with mass spectrometers can easily and efficiently perform analysis. While delivering operational convenience on par with an LC detector, the LCMS-2050 can rapidly analyze compounds over a wide mass range with high sensitivity.
Key features/benefits: - Combined Dual Ion Source (heated electrospray and atmospheric pressure ionization) can analyze a wide range of compounds from multiple chemical classes
- Ultrafast technology, including a 15,000 u/sec scan speed and polarity switching time of 10 msec, maintains high data quality while improving overall throughout
- Can be incorporated as one component in an LC system
- Can be used like an LC that operators simply turn on and use, enabling everything from MS data acquisition to data analysis
- Vacuum system starts up in only six minutes for MS data acquisition
- System Check function – injects a standard sample automatically, checks the mass accuracy, resolution, and spectral intensity, as well as instrument status
- Easy system maintenance maximizes instrument uptime
The LabSolutions LCMS workstation for the LCMS-2050 can control the LC and MS instruments simultaneously. MS data and data obtained from other LC detectors can be analyzed on the same date review platform. It is also equipped with Analytical Intelligence functions for data analysis to make laboratory operations more efficient. The LC/MS chromatograms and UV/MS spectra can be displayed in a single window, which makes it easy to review data. Mass information can also be annotated on the UV chromatogram.... Read More | Incorporating Shimadzu’s proprietary ultrafast technologies (UF Technologies), the triple quadrupole LCMS-8050RX offers outstanding measurement speeds and quantitative performance.
Specific and highly sensitive Multiple Reaction Monitoring (MRM) multi-component analysis is improved with a heated Incorporating Shimadzu’s proprietary ultrafast technologies (UF Technologies), the triple quadrupole LCMS-8050RX offers outstanding measurement speeds and quantitative performance.
Specific and highly sensitive Multiple Reaction Monitoring (MRM) multi-component analysis is improved with a heated electrospray source and ultra-efficient collision cell.
Combine with Shimadzu’s world-leading UHPLC systems for an unmatched level of performance.
Features:
- Ultrafast polarity switching (5 msec) – maintains constant quality and sensitivity with no loss of quantitative accuracy
- Ultra-high-speed scan rate of 30,000 u/sec – obtains high-quality mass spectra, even during high-speed analysis
- Ultrafast MRM transition speeds, up to 555 MRMs per second
- Heated ESI probe – promotes the ionization of wide range of targeted compounds
- CoreSpray™ gas delivery system – enhances reliability by increasing gas flow and improving nebulizer coaxiality
- High-efficiency CID cell – maintains signal intensity and suppresses crosstalk, even for high-speed or simultaneous multicomponent analysis
- Performance Concierge – Automatically monitors system performance, provides proactive maintenance alerts, and reduces instrument downtime through predictive diagnostics
- Easy maintenance – Changing the ESI capillary and the desolvation line (DL) can be quickly replaced without breaking vacuum
Intuitive LabSolutions software allows for simplified instrument control, diverse data handling, and integration with regulatory compliance requirements.
Optional LabSolutions Insight data review software, supporting review-by-exception, dramatically improves the speed and efficiency of multi-analyte data analysis.
In addition, LabSolutions MRM Connect automates MRM optimization to create high sensitivity quantitative LC-MS/MS methods.
... Read More | The triple quad LCMS-8060RX utilizes proprietary technologies and more efficient ion transfer to achieve outstanding speed and sensitivity.
A heat-assisted electrospray ionization probe delivers a highly efficient desolvation process that promotes the ionization of a wide range of target compounds The triple quad LCMS-8060RX utilizes proprietary technologies and more efficient ion transfer to achieve outstanding speed and sensitivity.
A heat-assisted electrospray ionization probe delivers a highly efficient desolvation process that promotes the ionization of a wide range of target compounds while the systems unique IonFocus™ electrode efficiently delivers ions into the mass spectrometer, resulting in lower noise levels, superior data quality and reduced maintenance needs.
Additional features include:
- CoreSpray™ gas delivery system – enhances reliability by increasing gas flow and improving nebulizer coaxiality.
- Ultrafast high-voltage power supply – enables sensitive and stable signal detection
- UFsweeper Collision Cell – delivers fast and accurate MRM quantitation; high-speed and high-efficiency CID occurs as ions are accelerated through the cell, enabling multi-component analysis with little signal degradation or crosstalk
- Scan speed of 30,000 u/s
- 5 ms polarity switching time
- Ultra-fast MRM measurements up to 555 ch/sec
- IonFocus™ electrode – effectively removes matrix contaminants, resulting in lower noise levels, superior data quality and reduced maintenance needs
- Easy maintenance – Consumable parts like the ESI spray needle and the inlet desolvation line (DL) can be changed quickly and easily without breaking vacuum.
- Performance Concierge – Automatically monitors system performance, provides proactive maintenance alerts, and reduces instrument downtime through predictive diagnostics.
LabSolutions LCMS workstation software offers total operator support, from analysis to data processing.
The LabSolutions Connect/LabSolutions Insight platform supports the entire analysis workflow, including:
- Project file management
- Optimization of MRM and interface parameters
- Efficient verification of quantitative results
- Simple method and batch creation
- Verification of quantitative results
... Read More | The LCMS-8065XE introduces innovative technologies that deliver exceptional performance with evolved, efficient and exact capabilities.
The instrument incorporates Shimadzu’s complete Ultra Fast Mass Spectrometry (UFMS) technology suite:
- World-class 5 msec positive/negative ion switching with
The LCMS-8065XE introduces innovative technologies that deliver exceptional performance with evolved, efficient and exact capabilities.
The instrument incorporates Shimadzu’s complete Ultra Fast Mass Spectrometry (UFMS) technology suite:
- World-class 5 msec positive/negative ion switching with zero signal loss
- Ultra-fast MRM acquisition up to 555 channels/sec
- Scanning up to 30,000 u/sec with maximum ion transmittance
- Advanced UF-Qarray™II & UF-Lens™ II ion guides for maximum transmission efficiency
New advancements include:
- StreamFocus Ionization Technology – The LCMS-8065XE features a low-dispersion nebulizer nozzle that dramatically reduces liquid droplet dispersion while maximizing ion intake efficiency. This breakthrough reduces nebulizer gas consumption by up to 7-fold compared to conventional ESI sources and achieves exceptional sensitivity improvements, particularly in negative mode.
- Enhanced IonFocus Performance – The evolved IonFocus unit utilizes a focusing electrode to selectively guide ions into the intake port while excluding neutral matrix components. This ensures sensitivity even when the ion spray is positioned further from the intake port, delivering superior robustness for long-term analysis.
- UFsweeper™ IV Collision Cell – The next-generation collision cell features a larger inlet lens diameter and an increased number of lenses for improved ion throughput, enhanced ion transmission, and dramatically improved sensitivity and quantitative precision.
- Performance Concierge – Automatically monitors system performance, provides proactive maintenance alerts, and reduces instrument downtime through predictive diagnostics. Peakintelligence for LCMS delivers revolutionary AI-driven peak detection with up to 67% reduction in manual review time and superior reproducibility across complex analyses.
The LCMS-8065XE excels across environmental monitoring, food safety, pharmaceutical analysis, clinical research, and industrial quality control applications.
It particularly excels for analysis of PFAS.
The LCMS-8065XE demonstrates remarkable capabilities with sub-ng/L detection limits for PFAS compounds in drinking water using direct injection.
The system delivers 3–48 fold sensitivity enhancement compared to previous generation instruments while maintaining exceptional stability – over 85% of initial response retained after more than 10,000 consecutive injections of complex wastewater samples (RSD <7%)
LabSolutions LCMS workstation software offers total operator support, from analysis to data processing.
The LabSolutions Connect/LabSolutions Insight platform supports the entire analysis workflow:
- Project file management
- Optimization of MRM and interface parameters
- Efficient verification of quantitative results
- Simple method and batch creation
- Verification of quantitative results
... Read More |