| Description | The Nexera QX Multiplex LC-MS/MS System uses multiple, alternating sample introduction streams for continuous operation of the mass spectrometer to significantly increase laboratory throughput and profitability.
- Multiple stream technology eliminates waiting for column equilibration and system
The Nexera QX Multiplex LC-MS/MS System uses multiple, alternating sample introduction streams for continuous operation of the mass spectrometer to significantly increase laboratory throughput and profitability.
- Multiple stream technology eliminates waiting for column equilibration and system flushing
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UHPLC autosamplers, stream-dedicated injection valves and washing pumps deliver ultra-fast performance with ultra-low carryover
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Automates flow line rinsing of each analytical stream to mitigate carryover from extreme samples
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Online sample cleanup – Automated online sample preparation avoids errors caused by manual handling and maximizes throughput.
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Multiple configurations available
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Utilizes the LCMS-8060NX triple quadrupole mass spectrometer, which delivers industry-leading robustness, sensitivity and detection speeds.
Dedicated QX Solution software offers a single point of control for multiple UHPLC streams and the mass spectrometer. By incorporating Analytical Intelligence, such as automatic carryover detection and evaluation, automatic rinsing, and high-concentration automatic detection, QX software ensures robust operation for prolonged unattended analysis.... Read More | Incorporating Shimadzu’s proprietary ultrafast technologies (UF Technologies), the triple quadrupole LCMS-8050RX offers outstanding measurement speeds and quantitative performance.
Specific and highly sensitive Multiple Reaction Monitoring (MRM) multi-component analysis is improved with a heated Incorporating Shimadzu’s proprietary ultrafast technologies (UF Technologies), the triple quadrupole LCMS-8050RX offers outstanding measurement speeds and quantitative performance.
Specific and highly sensitive Multiple Reaction Monitoring (MRM) multi-component analysis is improved with a heated electrospray source and ultra-efficient collision cell.
Combine with Shimadzu’s world-leading UHPLC systems for an unmatched level of performance.
Features:
- Ultrafast polarity switching (5 msec) – maintains constant quality and sensitivity with no loss of quantitative accuracy
- Ultra-high-speed scan rate of 30,000 u/sec – obtains high-quality mass spectra, even during high-speed analysis
- Ultrafast MRM transition speeds, up to 555 MRMs per second
- Heated ESI probe – promotes the ionization of wide range of targeted compounds
- CoreSpray™ gas delivery system – enhances reliability by increasing gas flow and improving nebulizer coaxiality
- High-efficiency CID cell – maintains signal intensity and suppresses crosstalk, even for high-speed or simultaneous multicomponent analysis
- Performance Concierge – Automatically monitors system performance, provides proactive maintenance alerts, and reduces instrument downtime through predictive diagnostics
- Easy maintenance – Changing the ESI capillary and the desolvation line (DL) can be quickly replaced without breaking vacuum
Intuitive LabSolutions software allows for simplified instrument control, diverse data handling, and integration with regulatory compliance requirements.
Optional LabSolutions Insight data review software, supporting review-by-exception, dramatically improves the speed and efficiency of multi-analyte data analysis.
In addition, LabSolutions MRM Connect automates MRM optimization to create high sensitivity quantitative LC-MS/MS methods.
... Read More | The LCMS-8065XE introduces innovative technologies that deliver exceptional performance with evolved, efficient and exact capabilities.
The instrument incorporates Shimadzu’s complete Ultra Fast Mass Spectrometry (UFMS) technology suite:
- World-class 5 msec positive/negative ion switching with
The LCMS-8065XE introduces innovative technologies that deliver exceptional performance with evolved, efficient and exact capabilities.
The instrument incorporates Shimadzu’s complete Ultra Fast Mass Spectrometry (UFMS) technology suite:
- World-class 5 msec positive/negative ion switching with zero signal loss
- Ultra-fast MRM acquisition up to 555 channels/sec
- Scanning up to 30,000 u/sec with maximum ion transmittance
- Advanced UF-Qarray™II & UF-Lens™ II ion guides for maximum transmission efficiency
New advancements include:
- StreamFocus Ionization Technology – The LCMS-8065XE features a low-dispersion nebulizer nozzle that dramatically reduces liquid droplet dispersion while maximizing ion intake efficiency. This breakthrough reduces nebulizer gas consumption by up to 7-fold compared to conventional ESI sources and achieves exceptional sensitivity improvements, particularly in negative mode.
- Enhanced IonFocus Performance – The evolved IonFocus unit utilizes a focusing electrode to selectively guide ions into the intake port while excluding neutral matrix components. This ensures sensitivity even when the ion spray is positioned further from the intake port, delivering superior robustness for long-term analysis.
- UFsweeper™ IV Collision Cell – The next-generation collision cell features a larger inlet lens diameter and an increased number of lenses for improved ion throughput, enhanced ion transmission, and dramatically improved sensitivity and quantitative precision.
- Performance Concierge – Automatically monitors system performance, provides proactive maintenance alerts, and reduces instrument downtime through predictive diagnostics. Peakintelligence for LCMS delivers revolutionary AI-driven peak detection with up to 67% reduction in manual review time and superior reproducibility across complex analyses.
The LCMS-8065XE excels across environmental monitoring, food safety, pharmaceutical analysis, clinical research, and industrial quality control applications.
It particularly excels for analysis of PFAS.
The LCMS-8065XE demonstrates remarkable capabilities with sub-ng/L detection limits for PFAS compounds in drinking water using direct injection.
The system delivers 3–48 fold sensitivity enhancement compared to previous generation instruments while maintaining exceptional stability – over 85% of initial response retained after more than 10,000 consecutive injections of complex wastewater samples (RSD <7%)
LabSolutions LCMS workstation software offers total operator support, from analysis to data processing.
The LabSolutions Connect/LabSolutions Insight platform supports the entire analysis workflow:
- Project file management
- Optimization of MRM and interface parameters
- Efficient verification of quantitative results
- Simple method and batch creation
- Verification of quantitative results
... Read More | Shimadzu’s LCMS RX series of triple quadrupole mass spectrometry instruments are supported by integrated hardware and software technologies to ensure ultrafast performance and reliable, robust results at lower operating costs, even under the most challenging and dynamic laboratory environments. The Shimadzu’s LCMS RX series of triple quadrupole mass spectrometry instruments are supported by integrated hardware and software technologies to ensure ultrafast performance and reliable, robust results at lower operating costs, even under the most challenging and dynamic laboratory environments. The RX Series incorporates patented Ultra Fast Mass Spectrometry (UFMS) technologies to deliver a polarity switching time of 5 msec, data acquisition scan speed of 30,000 u/sec, and ultra-fast MRM measurements up to 555 ch/sec, setting a new standard for dependable data acquisition and robust performance.
A suite of innovative technologies introduced with the RX series sets a new benchmark for reliability, resilience and responsibility:
- CoreSpray™ gas delivery system – enhances reliability by increasing gas flow and improving nebulizer coaxiality. This improves the heat distribution of the ionization source, ensuring unparalleled sample ionization, significantly enhancing the reliability of analytical data.
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IonFocus™ electrode – effectively removes matrix contaminants, resulting in lower noise levels, superior data quality and reduced maintenance needs.
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Heated ESI Probe – promotes the ionization of wide range of targeted compounds
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Performance Concierge – proactively evaluates system performance with a standard solution, troubleshoots problems, and notifies operators of maintenance needs, effectively minimizing instrument downtime.
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Enhanced software capabilities – autonomously monitor the system, reducing the need for manual intervention
The RX series consists of the following models:
- LCMS-8060RX: premier system offers world-class sensitivity, rapid analysis capabilities and remarkable robustness
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LCMS-8050RX: high-speed operation, excellent sensitivity, and trusted reliability in a robust, easy-to-use design
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LCMS-8045RX: ideal for routine analysis, delivering a balance of robustness, sensitivity and cost-effectiveness
The LCMS RX series enables responsible operation for lower laboratory costs and reduced environmental impact. These instruments provide an Ecology Mode function that automatically checks system status and shuts the instrument down after sample queues are completed. This reduction in power consumption minimizes the running cost of the laboratory and consumes less resources.... Read More | Covering the complete range from micro (0.1 µL/min) to semi-micro (500 µL/min), Nexera Mikros allows operators to realize high sensitivity with the reliability and ruggedness of HPLC. A newly designed micro ESI source provides greater than ten times the sensitivity of standard UHPLC-MS Covering the complete range from micro (0.1 µL/min) to semi-micro (500 µL/min), Nexera Mikros allows operators to realize high sensitivity with the reliability and ruggedness of HPLC. A newly designed micro ESI source provides greater than ten times the sensitivity of standard UHPLC-MS systems, while the system’s UF-Link allows operators to correctly and easily connect any microflow column to ensure a zero-dead volume connection every time.
- Sensitivity gains of greater than 10X can be seen over conventional LCMS for assays of small molecules, peptides and proteins.
- Micro-ESI LCMS source designed for optimal sensitivity and ease of use. An X–Y adjustable stage and viewing camera allow for easy ESI spray needle adjustment
- Column oven mounted on the LCMS to minimize the volume between the exit of the column and the ESI needle.
- Proprietary UF-Link technology makes robust and correct connections of microflow columns a breeze
- Fast, accurate, reproducible autosampler with extremely low carry-over; injection volume ranges from 0.1 to 50 µL
- Consistent peak retention times and peak areas
... Read More |