Cell disruptors operate with the goal of lysing cells in order to recover biomolecules of interest from within the cell. To date, there are a number of techniques used in cell disruption. These include milling, ultrasonication, bead breaking, French Press, chemical lysis, and high-pressure homogenizers. In selecting which approach of cell disruption to take, it is important to assess the nature of the sample, the required level of purity, and the volume needed to be processed.
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| Company | Genizer LLC | Genizer LLC | Genizer LLC |
| Item | High Pressure Micromix Homogenizer MixGenizer | NanoGenizer Laboratory-scale High Pressure Homogenizer | ProdGenizer (Dual Pump) |
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| Catalog Number | Mix Genizer | NanoGenizer | ProdGenizer |
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| Pressure Range | Up to 30,000 psi | up to 45000 psi | 5,000 – 30,000 psi (model dependent) |
| Description | MixGenizer is a homogenizer specially for mixing and homogenizing the sample fluids from two or more inlet ports. The two streams are injected into the Genizer ultra high pressure dual pumps from the inlet reservoir and mix homogenously at the diamond mixing chamber where the fluids pass through theMixGenizer is a homogenizer specially for mixing and homogenizing the sample fluids from two or more inlet ports. The two streams are injected into the Genizer ultra high pressure dual pumps from the inlet reservoir and mix homogenously at the diamond mixing chamber where the fluids pass through the fixed micro-channels and experience high shears and strong impacts. It can be used for laboratory preparation of liposomes, nanosuspensions, microemulsions, lipid microsphere, nanoprecipitations, nanoemulsions, nanocrystals, infusion solutions, fine chemical reaction and etc.
Features - Diamond Interaction Chamber (Electro-Polish and Passivation for pharmaceutical application).
- 50mL Syringe or S/S cylinder inlet & outlet reservoir as options.
- Warranty period as long as one year against any manufacturing defects.
- Tools & Spare.
Advantages - Energy efficient, 1/2 energy loss of the most homogenizers.
- Small (integrated design delivers the light weight and small dimensions).
- Smart (programming control systems confer diligent functions: controlled inlet volume ± 0.1mL; auto stop with time/volume).
- Silent (noiseless performance).
- Strong (more than 100 mL/min at 30,000 psi).
- CE compliant and RoHs compliant.
... Read More | The NanoGenizer is a user-friendly, laboratory-scale high pressure homogenizer that is designed for laboratory R&D and small-scale production at ultra-high pressure. It's powered by a single-phase electrical outlet. No need for compressed air or hydraulic oil. Maximum working pressure up to 3,062 The NanoGenizer is a user-friendly, laboratory-scale high pressure homogenizer that is designed for laboratory R&D and small-scale production at ultra-high pressure. It's powered by a single-phase electrical outlet. No need for compressed air or hydraulic oil. Maximum working pressure up to 3,062 bar (45,000 psi).
The main features of the NanoGenizer are: - Pressure: 25,000 psi, 30,000 psi, 45,000psi
- Minimum sample volume: 5 mL
- Flow rate (water value): ~100 mL / min
- Weight: ~35 kg
- Application: Nano emulsions, Fat emulsions, Liposomes, Cell disruption, Nano dispersion, Deagglomeration
The NanoGenizer features a microfluidics Diamond Interaction Chamber with nano-size microchannels inside the chamber where your formulation is subjected to forces of high shear and strong impact and result in nano particle dispersion and nano cell disruption.
Using the Diamond Interaction Chamber technology, the NanoGenizer can be widely used in the pharmaceutical, biochemical, cosmetics, food and dairy industries among others. It can also support experimentations from particle size reduction to cell disruption, nano emulsions, nano dispersions, liposome and more.
Features: - Diamond Interaction Chamber (Electro-Polish and Passivation for pharmaceutical application)
- Glass and 316L stainless steel feed reservoir as options
- Ceramic plunger
- Warranty period as long as one year against any manufacturing defects.
- Tools & Spare
Advantages: - Energy efficient, 1/2 energy loss of the most homogenizers
- Easy-to-operate touch screen PLC : stroke volume setting, auto stop with time/volume.
- Silent (Noiseless performance)
- CE compliant and RoHs compliant
... Read More | The ProdGenizer is a prod-scale ultra-high-pressure homogenizer and cell disruptor from Genizer LLC. It is electric-driven and gives formulation development experts more alternatives and capacities for cell disruption, emulsification and particle size reduction quickly and easily. The ProdGenizer The ProdGenizer is a prod-scale ultra-high-pressure homogenizer and cell disruptor from Genizer LLC. It is electric-driven and gives formulation development experts more alternatives and capacities for cell disruption, emulsification and particle size reduction quickly and easily. The ProdGenizer dual pumps system is based on a digital control design and is simple to use, with an auxiliary diamond chamber that helps pre-mix the sample and aids the nano-sizing procedure, as well as a primary diamond interaction chamber that disrupts the cell and reduces particle size. In the sample cooling unit, a 316 L stainless heat exchanger is employed to help cool the samples.
Features - Diamond Interaction Chamber (Electro-Polish and Passivation for pharmaceutical application).
- Auxiliary Diamond Interaction Chamber.
- 316 S/S heat exchanger.
- Feed reservoir: Capacity 2L, 316L stainless steel.
- Tools & Spare.
Advantages - Energy efficient, 1/2 energy loss of the most homogenizers.
- Small (integrated design delivers the light weight and small dimensions).
- Smart (programming control systems confer diligent functions: controlled inlet volume ± 0.1mL; auto stop with time/volume).
- Silent (noiseless performance).
- Strong (~60 L/H at 30,000 psi).
- CE compliant and RoHs compliant.
... Read More |
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