Capillary electrophoresis instruments enable to the separation of charged molecules from each other. Unlike standard SDS-PAGE separation, capillary electrophoresis systems can provide molecule detection after separation through a light source and detector and the system can utilize high voltages without overheating the samples. Applications for capillary electrophoresis instruments include pharmaceutical (i.e. digest analysis of biopharma drugs; peptide mapping), life science (i.e., protein/peptide separation, DNA analysis, and PCR product analysis, chemical (i.e. raw material analysis), forensics (i.e. drug and explosive analysis), environmental (i.e. pesticide analysis) and food/beverage (i.e. as organic acid analysis).
Consideration when purchasing a capillary electrophoresis system:
Capillary electrophoresis provides additional advantages over other analysis methods, like HPLC, GC, SDS-PAGE, which include speed, cost of analysis, and easy method development. First consideration is the type of system required. There are several methods of capillary electroseparation, which include capillary zone electrophoresis, capillary isoelectric focusing, capillary gel electrophoresis, and more. Second consideration is the system’s throughput; how many samples can the instrument run.
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| Company | Bio-Techne | Bio-Techne | Bio-Techne |
| Item | Maurice C | Maurice | Maurice S |
| Catalog Number | 090-002 | 090-000 | 090-001 |
| Price | | | |
| Description | Maurice C. is a cIEF-only capillary electrophoresis instrument from ProteinSimple (Bio-Techne) designed for identity and charge heterogeneity analysis of mAbs, ADCs, and vaccines. It uses proprietary imaged capillary isoelectric focusing (icIEF) technology with whole-column detection, providing bothMaurice C. is a cIEF-only capillary electrophoresis instrument from ProteinSimple (Bio-Techne) designed for identity and charge heterogeneity analysis of mAbs, ADCs, and vaccines. It uses proprietary imaged capillary isoelectric focusing (icIEF) technology with whole-column detection, providing both UV absorbance and native fluorescence data. Features ready-to-use cIEF cartridges, on-board sample mixing, and compatibility with Compass for iCE and Waters Empower software for 21 CFR compliance.... Read More | Maurice is a capillary electrophoresis instrument from ProteinSimple (Bio-Techne) that automates protein profiling by size or charge. It supports both cIEF and CE-SDS applications for mAbs, ADCs, fusion proteins, peptides, and vaccines. Features prequalified ready-to-use cartridges, on-board sample Maurice is a capillary electrophoresis instrument from ProteinSimple (Bio-Techne) that automates protein profiling by size or charge. It supports both cIEF and CE-SDS applications for mAbs, ADCs, fusion proteins, peptides, and vaccines. Features prequalified ready-to-use cartridges, on-board sample mixing, and is compatible with Compass for iCE and Waters Empower software for 21 CFR compliance.... Read More | Maurice S. is a CE-SDS-only capillary electrophoresis instrument from ProteinSimple (Bio-Techne) designed for IgG purity and heterogeneity analysis via size separations. Features ready-to-go CE-SDS PLUS and Turbo CE-SDS cartridges providing IgG purity data in as little as 5.5 minutes. Delivers heavyMaurice S. is a CE-SDS-only capillary electrophoresis instrument from ProteinSimple (Bio-Techne) designed for IgG purity and heterogeneity analysis via size separations. Features ready-to-go CE-SDS PLUS and Turbo CE-SDS cartridges providing IgG purity data in as little as 5.5 minutes. Delivers heavy chain, light chain, and HC vs. NGHC composition data with CVs under 2%. Compatible with Compass for iCE and Waters Empower software for 21 CFR compliance.... Read More |
| Type | Capillary Electrophoresis (CE) Instrument — imaged capillary isoelectric focusing (icIEF) only | Capillary Electrophoresis (CE) Instrument — imaged capillary isoelectric focusing (icIEF) and CE-SDS | Capillary Electrophoresis (CE) Instrument — CE-SDS (size-based separation) only |
| Applications | Charge heterogeneity and identity analysis (cIEF/icIEF); pI determination; charge variant profiling of mAbs, ADCs, vaccines; biopharmaceutical QC/QA and method development; GMP/21 CFR Part 11 compliant environments | Protein purity, identity and charge heterogeneity analysis; cIEF (charge variants, pI determination); CE-SDS (size-based purity, heavy chain / light chain / NGHC content); mAbs, ADCs, fusion proteins, peptides, vaccines, virus-like particles; biopharmaceutical QC/QA, GMP/21 CFR Part 11 compliance | IgG purity and heterogeneity analysis by size (CE-SDS); heavy chain, light chain, and NGHC content determination; mAb characterization; biopharmaceutical QC/QA and method development; GMP/21 CFR Part 11 compliant environments |
| Number of Samples | 100 guaranteed injections per cartridge, 200 maximum; maximum 100 injections per batch. Sample tray options: 96-well plates or 48 vials | Maximum 100 injections per batch (cIEF); maximum 48 injections per batch (CE-SDS PLUS); maximum 96 injections per batch (Turbo CE-SDS). Sample tray options: 96-well plates or 48 vials | CE-SDS PLUS: maximum 48 injections per batch; Turbo CE-SDS: maximum 96 injections per batch. Sample tray options: 96-well plates or 48 vials |
| Voltage | Pre-focusing: 1500 V; Focusing: 3000 V | cIEF: Pre-focusing 1500 V, Focusing 3000 V; CE-SDS PLUS: Separation 5750 V; Turbo CE-SDS: Separation 4200 V | CE-SDS PLUS: Separation 5750 V; Turbo CE-SDS: Separation 4200 V |
| Dimensions | 44 cm H x 42 cm W x 61 cm D | 44 cm H x 42 cm W x 61 cm D | 44 cm H x 42 cm W x 61 cm D |
| Detector(s) | UV Absorbance at 280 nm; Native Fluorescence (Ex 280 nm, Em 320–450 nm) | cIEF: UV Absorbance at 280 nm; Native Fluorescence (Ex 280 nm, Em 320–450 nm). CE-SDS PLUS: UV Absorbance at 220 nm. Turbo CE-SDS: UV Absorbance at 220 nm | CE-SDS PLUS: UV Absorbance at 220 nm; Turbo CE-SDS: UV Absorbance at 220 nm |
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