Capillary electrophoresis instruments enable to the separation of charged molecules from each other. Unlike standard SDS-PAGE separation, capillary electrophoresis systems can provide molecule detection after separation through a light source and detector and the system can utilize high voltages without overheating the samples. Applications for capillary electrophoresis instruments include pharmaceutical (i.e. digest analysis of biopharma drugs; peptide mapping), life science (i.e., protein/peptide separation, DNA analysis, and PCR product analysis, chemical (i.e. raw material analysis), forensics (i.e. drug and explosive analysis), environmental (i.e. pesticide analysis) and food/beverage (i.e. as organic acid analysis).
Consideration when purchasing a capillary electrophoresis system:
Capillary electrophoresis provides additional advantages over other analysis methods, like HPLC, GC, SDS-PAGE, which include speed, cost of analysis, and easy method development. First consideration is the type of system required. There are several methods of capillary electroseparation, which include capillary zone electrophoresis, capillary isoelectric focusing, capillary gel electrophoresis, and more. Second consideration is the system’s throughput; how many samples can the instrument run.
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| Company | Qiagen | Qiagen |
| Item | QIAxcel Connect | QIAxcel Advanced |
| Price | | |
| Description | Automated capillary electrophoresis instrument for fast, high-sensitivity, high-resolution DNA fragment analysis and RNA QC using ready-to-run gel cartridges. Includes laptop with QIAxcel ScreenGel Software and 1-year warranty. | Automated capillary electrophoresis system for DNA and RNA quality control, genotyping, and NGS library preparation. Provides fast, precise, and reliable results with digital data collection. |
| Type | Capillary Electrophoresis System | Capillary Electrophoresis System |
| Applications | DNA fragment analysis, RNA quality control, NGS library QC, cell-free DNA (cfDNA) QC, high-resolution genotyping, multiplex PCR screening, HLA typing, liquid biopsy, FFPE sample analysis | DNA quality control, RNA quality control, genotyping, NGS library preparation |
| Number of Samples | Up to 96 samples per run (12 samples at a time) | 12 samples at a time, up to 96 samples per run |
| Detector(s) | Fluorescence detection via intercalating dye with photomultiplier tube | Light-excitable intercalating agent with photomultiplier tube |
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