Capillary electrophoresis instruments enable to the separation of charged molecules from each other. Unlike standard SDS-PAGE separation, capillary electrophoresis systems can provide molecule detection after separation through a light source and detector and the system can utilize high voltages without overheating the samples. Applications for capillary electrophoresis instruments include pharmaceutical (i.e. digest analysis of biopharma drugs; peptide mapping), life science (i.e., protein/peptide separation, DNA analysis, and PCR product analysis, chemical (i.e. raw material analysis), forensics (i.e. drug and explosive analysis), environmental (i.e. pesticide analysis) and food/beverage (i.e. as organic acid analysis).
Consideration when purchasing a capillary electrophoresis system:
Capillary electrophoresis provides additional advantages over other analysis methods, like HPLC, GC, SDS-PAGE, which include speed, cost of analysis, and easy method development. First consideration is the type of system required. There are several methods of capillary electroseparation, which include capillary zone electrophoresis, capillary isoelectric focusing, capillary gel electrophoresis, and more. Second consideration is the system’s throughput; how many samples can the instrument run.
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| Company | Qiagen | Qiagen |
| Item | QIAxcel Advanced | QIAxcel Connect |
| Price | | |
| Description | Automated capillary electrophoresis system for DNA and RNA quality control, genotyping, and NGS library preparation. Provides fast, precise, and reliable results with digital data collection. | Automated capillary electrophoresis instrument for fast, high-sensitivity, high-resolution DNA fragment analysis and RNA QC using ready-to-run gel cartridges. Includes laptop with QIAxcel ScreenGel Software and 1-year warranty. |
| Type | Capillary Electrophoresis System | Capillary Electrophoresis System |
| Applications | DNA quality control, RNA quality control, genotyping, NGS library preparation | DNA fragment analysis, RNA quality control, NGS library QC, cell-free DNA (cfDNA) QC, high-resolution genotyping, multiplex PCR screening, HLA typing, liquid biopsy, FFPE sample analysis |
| Number of Samples | 12 samples at a time, up to 96 samples per run | Up to 96 samples per run (12 samples at a time) |
| Detector(s) | Light-excitable intercalating agent with photomultiplier tube | Fluorescence detection via intercalating dye with photomultiplier tube |
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