Dissolution media preparation systems are used to quickly and safely remove dissolved gases prior to dissolution testing (measurement of the rate of drug release in the body).
What Is a Dissolution Media Preparation System?
These instruments can simultaneously process multiple vessels using a combination of heating (for example, ambient to 45 °C), vacuum, circulation, and dispensing. The appropriate volumes of acid, buffer, or surfactant are also added automatically if required. Common tank sizes include 8 or 15 L.
Applications of Dissolution Media Preparation Systems
Preparation of dissolution media, including elimination of air bubbles and dissolved gases, is a vital part of tablet testing in the pharmaceutical industry, since the presence of dissolved gases can lead to false absorbance readings in dissolution testing. Automated degassing and dosing also help ensure compliance with USP and FDA requirements.
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