| Description | The Opt-Diss 410 brings dissolution measurement directly to the vessel, eliminating the need for manual or automated sampling along with the associated consumables, labor, and off-line analysis. Choose from patented ARCH probes, designed specifically for dissolution testing with negligible The Opt-Diss 410 brings dissolution measurement directly to the vessel, eliminating the need for manual or automated sampling along with the associated consumables, labor, and off-line analysis. Choose from patented ARCH probes, designed specifically for dissolution testing with negligible hydrodynamic impact, or the new patent-pending Variprobe Adjustable Pathlength Dip Probe, which easily adjusts between 2 mm, 5 mm, 10 mm, and 20 mm pathlengths to accommodate a range of sample concentrations. By moving light rather than liquids, the in-situ fiber optic UV system of the Opt-Diss 410 removes the need for filters, tubing, and syringes, saving time, labor, and costs, while enabling near real-time data collection with sample points as frequent as every five seconds.
SIMPLE & EFFICIENT DISSOLUTION TESTING
Automated data collection and analysis take the test from start to report in real-time, with no operator interaction required. Data can be collected as frequently as every 5 seconds, with no extra effort.
MULTICOMPONENT ANALYSIS
Measure two components in the same dissolution test without the need for LC, including products with two APIs or interaction with excipients, coatings, capsules, or any other source of deviation of the UV spectra.
RAPID AND ROUTINE DATA COLLECTION
With acquisition speeds as fast as 5 seconds for all vessels, collecting near real-time dissolution profiles is ideal for formulators to understand complicated release dynamics as it occurs.
INDUSTRY APPROVED
Leading pharmaceutical companies, along with the FDA and USP, have adopted the Opt-Diss by Distek.
IN-SITU UV MEASUREMENTS
Keeping the science in the vessel! The Opt-Diss 410 measures directly in the vessel, eliminating manual or automated sampling along with the associated consumables, labor, and off-line analysis.
- Choose from patented ARCH probes designed specifically for dissolution testing with negligible hydrodynamic effect
- Or Distek's new patent-pending Variprobe Adjustable Pathlength Dip Probe. Easily switch between 2 mm, 5 mm, 10 mm, and 20 mm pathlengths to accommodate a range of sample concentrations.
SINGLE SOFTWARE PACKAGE
21 CFR Part 11 compliant, the Opt-Diss 410 is the only fully integrated UV fiber optic dissolution solution with a single software package controlling the entire system.... Read More | The Distek Model 2500 Dissolution System offers great flexibility and configurability. It can be configured as USP Apparatus 1, 2, 5, and 6, plus intrinsic dissolution. The extensiveusers method, and reporting storage capabilities are enabled by a brilliant touch screen. Unparalleled control of the The Distek Model 2500 Dissolution System offers great flexibility and configurability. It can be configured as USP Apparatus 1, 2, 5, and 6, plus intrinsic dissolution. The extensiveusers method, and reporting storage capabilities are enabled by a brilliant touch screen. Unparalleled control of the instrument,t plus automatic storage of component serial numbers and automatic qualification reminders, makes the Model 2500 robust and reliable enough for QC applications yet flexible enough for R&D use.
- VOLUME FLEXIBILITY
Accommodates up to 8 vessels ranging in size from 100 mL (utilizing Distek’s small volume conversion kit) to 2L, allowing the user to run a diverse range of tests.
- SELF-PRIMING WATER CIRCULATOR / HEATER
The self-priming design and precise microprocessor control allow for improved temperature uniformity and reduced heating times. The low-profile design allows the circulator to be stowed behind the bath, requiring no additional bench space.
- ELECTRONIC QUALIFICATION GUIDANCE
Settable automatic electronic instrument requalification reminders eliminate missed validation dates and ensure continuous instrument uptime.
- COLOR TOUCH SCREEN DISPLAY
The icon-driven user interface lowers overall cost by reducing training time and user errors while maximizing productivity and command of the dissolution test.
- QUICK CHANGE PADDLES AND BASKETS
Interchangeable stirring elements coupled with the automatic height adjustment provide a fast transition between Apparatus 1 and 2 without having to remove the shaft.
- AUTOMATIC HEIGHT ADJUSTMENT
Setting the height is done through a one-time adjustment and the utilization of the interchangeable paddles and baskets.
- WAKE UP AND SLEEP MODE
Programmable wake-up and sleep modes allow the user to schedule thermocirculator start-up and shutdown times to save time and conserve energy.
... Read More | The Distek Model 2500 RTD Dissolution System offers great flexibility and configurability. It can be configured as USP Apparatus 1, 2, 5, and 6, plus intrinsic dissolution. The extensive user, method, and reporting storage capabilities are enabled by a brilliant touchscreen. Patented wireless The Distek Model 2500 RTD Dissolution System offers great flexibility and configurability. It can be configured as USP Apparatus 1, 2, 5, and 6, plus intrinsic dissolution. The extensive user, method, and reporting storage capabilities are enabled by a brilliant touchscreen. Patented wireless temperature sensors continuously monitor and display the in-vessel temperature for each vessel. Unparalleled control of the instrument, plus automatic storage of component serial numbers and automatic qualification reminders, makes the Model 2500 RTD robust and reliable enough for QC applications yet flexible enough for R&D use.
WIRELESS IN-SHAFT TEMPERATURE SENSORS
Patented wireless temperature sensors control and monitor the temperature.
- Continuously monitor, display, and record the in-vessel temperature for each vessel
- Ensure and document temperature compliance throughout the entire dissolution test
- Eliminate additional labor to measure the actual temperature in vessels
VOLUME FLEXIBILITY
Accommodates up to 8 vessels ranging in size from 100 mL (utilizing Distek’s small volume conversion kit) to 2L, allowing the user to run a diverse range of tests.
SELF-PRIMING CIRCULATOR / HEATER
The self-priming design and precise microprocessor control allow for improved temperature uniformity and reduced heating times. The low-profile design allows the circulator to be stowed behind the bath, requiring no additional bench space.
ELECTRONIC QUALIFICATION GUIDANCE
Settable automatic electronic instrument requalification reminders eliminate missed validation dates and ensure continuous instrument uptime.
COLOR TOUCH SCREEN DISPLAY
The icon-driven user interface lowers overall cost by reducing training time and user errors while maximizing productivity and command of the dissolution test.
QUICK CHANGE PADDLES AND BASKETS
Interchangeable stirring elements coupled with the automatic height adjustment provide a fast transition between Apparatus 1 and 2 without having to remove the shaft.
AUTOMATIC HEIGHT ADJUSTMENT
Setting the height is done through a one-time adjustment and the utilization of the interchangeable paddles and baskets.
WAKE UP AND SLEEP MODE
Programmable wake-up and sleep modes allow the user to schedule thermocirculator start-up and shutdown times to save time and conserve energy.
... Read More | The Distek Model 2500 Select builds on decades of patented bathless technology to deliver rapid media heating and significantly reduced energy consumption. Designed for flexibility, the Model 2500 Select supports USP Apparatus 1, 2, 5, and 6, along with intrinsic and small volume dissolution methodsThe Distek Model 2500 Select builds on decades of patented bathless technology to deliver rapid media heating and significantly reduced energy consumption. Designed for flexibility, the Model 2500 Select supports USP Apparatus 1, 2, 5, and 6, along with intrinsic and small volume dissolution methods. A user-friendly touchscreen interface offers ample storage for methods, reports, and user profiles. Wireless temperature sensors ensure continuous in-vessel monitoring for precise temperature control. With automated tracking of component serial numbers and built-in qualification reminders, the Model 2500 Select is a dependable solution for QC labs and a versatile tool for R&D environments.
BATHLESS HEATING
Eliminate the water bath, thermocirculator, and associated consumables with Bathless Heating. This energy-efficient technology rapidly heats media from ambient to 37°C in under 15 minutes and supports high temperature operations up to 99°C.
WIRELESS IN-SHAFT TEMPERATURE SENSORS
Our patented temperature sensors offer precise control and continuous monitoring within each vessel during dissolution test, ensuring compliance. They automatically monitor, display, and record temperatures, eliminating manual measurements and streamlining the testing process.
SERIALIZED COMPONENT TRACKING
Easily enter and track all serialized components - including paddles, baskets, basket adapters, shafts, and vessels. Shaft serial numbers auto-populate for added efficiency.
COLOR TOUCH SCREEN DISPLAY
The icon-driven user interface lowers overall cost by reducing training time and user errors while maximizing productivity and command of the dissolution test.
ELECTRONIC QUALIFICATION GUIDANCE
Automatic electronic instrument requalification reminders, which are easily configurable, eliminate missed validation dates, ensuring continuous instrument uptime.
QUICK CHANGE PADDLES AND BASKETS
The pairing of interchangeable stirring elements with automatic height adjustment allows for swift transitions between Apparatus 1 and 2 without the need to remove the shaft.
COMPLIANCE
The use of bathless heating fully complies with the requirements outlined in the USP, EP, ChP, BP, and JP Pharmacopoeias.... Read More | The Distek sensIR 3200 combines two exclusive technologies—bathless heating and Near-IR sensing—to deliver one of the most advanced and user-friendly disintegration testers available. Bathless heating not only shortens warm-up times but also reduces the maintenance and mess associated with The Distek sensIR 3200 combines two exclusive technologies—bathless heating and Near-IR sensing—to deliver one of the most advanced and user-friendly disintegration testers available. Bathless heating not only shortens warm-up times but also reduces the maintenance and mess associated with conventional water bath systems—resulting in a more efficient testing process.
To meet your throughput requirements, the sensIR 3200 is available in two, four, or six testing positions—offering maximum flexibility in the smallest footprint of any comparably equipped instrument.
BATHLESS HEATING
Patented Distek heater jackets raise media temperature from ambient to 37°C in under 8 minutes—doubling the number of tests that can be performed daily. The system uses significantly less electricity and requires no algicide, reducing overall operating costs.
AUTO ENDPOINT DETECTION
Optional Auto Endpoint Detection* uses Patent-Pending Near-Infrared technology to automatically monitor and record disintegration times and results. It operates without modified fluted disks, eliminating the need for method revalidation for products originally tested without using the modified fluted disks.
RUN MULTIPLE METHODS SIMULTANEOUSLY
Run up to three independent methods to test different products simultaneously and reduce method development time.
ADVANCED USER INTERFACE
The icon-driven user interface lowers overall cost by reducing training time and user errors. Features include storage for 100 reports, management of up to 50 users, qualification reminders, the ability to run multiple methods simultaneously, and more.
INTEGRATED TEMPERATURE SENSOR
Enables monitoring and documentation of individual beaker temperatures to support regulatory compliance, while eliminating the need to manually verify temperature equilibration before tablet introduction.
SCALABILITY
Available in 2, 4, or 6 positions, the semi-circle footprint maximizes bench space while scaling to match your productivity needs.
*The accuracy of auto endpoint detection may vary based on product and media types. Distek does not guarantee or warrant the use of NIR detection technology for all applications.
... Read More |