MicroCal PEAQ-ITC Calorimeters from Malvern Panalytical

Description

MicroCal ITC isothermal titration calorimeters all allow direct, label-free in solution measurement of binding affinity and thermodynamics in a single experiment, enabling the accurate determination of binding constants (KD), reaction stoichiometry (n), enthalpy (ΔH) and entropy (ΔS). This provides a complete thermodynamic profile of the molecular interaction. ITC goes beyond binding affinities and can elucidate the mechanisms underlying molecular interactions.

Malvern MicroCal PEAQ-ITC
The MicroCal PEAQ-ITC Automated combines the high sensitivity of the MicroCal PEAQ-ITC - the calorimeter core of the system - with walkaway automation, to meet the productivity needs of busy research and drug discovery laboratories.
Features:
  • User-friendly design tools assist in selecting experimental run parameters
  • All binding parameters (affinity, stoichiometry, enthalpy and entropy) in a single experiment
  • Quick to first result with minimal assay development, no labelling, no immobilization and no molecular weight limitations
  • High signal to noise gives more confidence in accessing data quality and relevance of generated affinity and thermodynamic parameters
  • Outstanding data quality for sub-millimolar to picomolar disassociation constants (10-2 to 10-12 M)
  • Coin shaped cell optimizes sample mixing
  • Nonreactive Hastelloy for chemical resistance and compatibility with biological samples
  • Sensitivity to investigate any biomolecular interaction using as little as 10µg of protein
  • Samples presented in temperature controlled 96-well plate
  • Fully automated system with walk-away operation for enhanced productivity
Malvern MicroCal PEAQ-ITC Automated
MicroCal PEAQ-ITC is designed for ease-of-use and exceptional sensitivity. MicroCal ITC is an essential tool for any research laboratory studying biomolecular interactions where high sensitivity and fast results are paramount.
Features:
  • User-friendly guided workflows with embedded help videos give any level of user the ability to generate high quality data
  • High signal to noise gives more confidence in accessing data quality and relevance of generated affinity and thermodynamic parameters
  • Automated washing with detergent of the sample cell and titration syringe assists in producing high quality reproducible data
  • All binding parameters (affinity, stoichiometry, enthalpy and entropy) in a single experiment
  • Quick to first results with no assay development, no labeling, no immobilization and no molecular weight limitations
  • Sensitivity to investigate any biomolecular interaction using as little as 10µg of protein
  • Directly measures millimolar to nanomolar affinities (KDS) (10-2 to 10-9 M)
  • Measures nanomolar to picomolar disassociation constants using competitive binding techniques (10-9 to 10-12M)
  • Nonreactive Hastelloy for chemical resistance and compatibility with biological samples
  • Compatible with non-aqueous solvents
  • Upgradable to fully automated MicroCal PEAQ-ITC Automated