Emory University Leverages Nanoink’s D Nanolithography to Quantify Forces Exerted By Single Receptor Molecules

Printing multi-component nanoscale arrays of tension sensors will advance understanding of mechano-transduction in living cells

CHICAGO – June 26, 2012 – NanoInk's NanoFabrication Systems Division is pleased to announce that Emory University recently purchased a Dip Pen Nanolithography® (DPN® ) system to quantify the forces exerted by single receptor molecules in real time across entire cells or tissues. Dip Pen Nanolithography is a direct write, tip-based lithography technique capable of multi-component deposition of a wide range of materials with nanoscale registry. It can fabricate multiplexed, customized patterns with feature sizes as small as 50 nanometers or as big as 10 microns on a variety of substrates including glass, plastic, gold and silicon. Emory is located in Atlanta, Ga. and is recognized internationally for its outstanding liberal arts college and as one of the nation's leading research universities.

"We are very excited about coupling Dip Pen Nanolithography with our newly developed method for force sensing to directly print nanoscale arrays of tension sensors. One of the biggest questions in the field of mechano-transduction pertains to the role of receptor clustering in force transmission. We plan on addressing this question by investigating the integrin, Notch, and EGF receptors using this hybrid nanotechnology-biophysics approach in living cells," said Khalid Salaita, assistant professor of Chemistry at Emory University. "I have used Dip Pen Nanolithography for almost a decade now and I'm confident that it will allow us to push the frontiers of understanding the mechano-chemistry of cells."

"Dip Pen Nanolithography provides a set of capabilities that that are not available in any other nanolithography method," said Tom Warwick, NanoInk's general manager of NanoInk's NanoFabrication Systems Division. "We look forward to seeing the innovations and breakthroughs that will soon come from Khalid Salaita and his team at Emory University using the high-throughput afforded by 2D DPN and Polymer Pen Lithography techniques."

Professor Salaita and Yoshie Narui, his graduate student, previously used Dip Pen Nanolithography to develop a new method for controlling ligand spatial organization that holds potential for investigating supramolecular protein assemblies in living cells. This work was published in the 2011 November issue of Chemical Science. The article titled, "Dip-pen nanolithography of optically transparent cationic polymers to manipulate spatial organization of proteolipid membranes," is available at: http://pubs.rsc.org/en/Content/ArticleLanding/2012/SC/C1SC00475A.

The Salaita Group at Emory University is a multidisciplinary research group focused on the areas of materials, biophysical and biological chemistry. It develops chemical tools to better understand how information (chemical and physical signals) is transmitted in living systems. More information is available at: http://chemistry.emory.edu/faculty/salaita/Home.html.

NanoInk's NanoFabrication Systems Division brings sophisticated nanofabrication to the laboratory desktop in an easy to use and affordable setting. Additional details can be found at: http://nanoink.net/products-services.html.

About NanoInk

NanoInk, Inc. is an emerging growth technology company specializing in nanometer-scale manufacturing and applications development for the life sciences, engineering, pharmaceutical, and education industries. Using Dip Pen Nanolithography® (DPN®), a patented and proprietary nanofabrication technology, scientists are enabled to rapidly and easily create micro-and nanoscale structures from a variety of materials on a range of substrates. This low cost, easy to use and scalable technique brings sophisticated nanofabrication to the laboratory desktop. Headquartered in the Illinois Science + Technology Park, north of Chicago, NanoInk currently has several divisions including the NanoFabrication Systems Division, the Nano BioDiscovery Division, the NanoProfessor® Division and the NanoGuardian™ Division. For more information on products and services offered by NanoInk, Inc., visit www.nanoink.net.

NanoInk, the NanoInk logo, Dip Pen Nanolithography, and DPN are registered trademarks of NanoInk, Inc.