9 July 2013: Malvern, UK: Malvern Instruments has published ‘Static Light Scattering Technologies For GPC/SEC Explained’, a valuable guide for anyone assessing the value of a light scattering detector for gel permeation/size exclusion chromatography (GPC/SEC).
Static light scattering delivers absolute molecular weight measurement within a GPC/SEC analysis
Covering the theory and practice of molecular weight measurements using static light scattering, this basic guide serves as both an introduction for those with no prior knowledge of the technique and a reference document for anyone looking to enhance their understanding. The white paper is available as a free download from the Malvern Instruments website at www.malvern.com/slsforgpc.
Light scattering detectors are used extensively within GPC/SEC detection systems to determine exact molecular mass, particularly in the development of polymer, protein and macromolecular species. The new white paper from Malvern Instruments explains the differences between all the light scattering techniques used in GPC/SEC detection including: Multiple Angle Light Scattering (MALS), Right Angle Light Scattering (RALS) and Low Angle Light Scattering (LALS). A key focus is the practical uses of these different technologies and their respective advantages and disadvantages for different applications.
Static Light Scattering (SLS) is widely used to determine the exact physical size or molecular weight of a molecule without the need for external calibration. Malvern offers a range of light scattering detectors. These are individually compatible with any GPC/SEC system or can be combined with refractive index, viscometry, and UV detectors in an integrated triple or tetra detection Viscotek system for comprehensive polymer, protein, and macromolecule characterization.
For more information on the theory and application of light scattering within GPC/SEC visit the Malvern website at www.malvern.com/sls
About Malvern Instruments
Malvern provides the materials and biophysical characterization technology and expertise that enables scientists and engineers to understand and control the properties of dispersed systems. These systems range from proteins and polymers in solution, particle and nanoparticle suspensions and emulsions, through to sprays and aerosols, industrial bulk powders and high concentration slurries. Used at all stages of research, development and manufacturing, Malvern’s materials characterization instruments provide critical information that helps accelerate research and product development, enhance and maintain product quality and optimize process efficiency.
Our products reflect Malvern’s drive to exploit the latest technological innovations and our commitment to maximizing the potential of established techniques. They are used by both industry and academia, in sectors ranging from pharmaceuticals and biopharmaceuticals to bulk chemicals, cement, plastics and polymers, energy and the environment.
Malvern systems are used to measure particle size, particle shape, zeta potential, protein charge, molecular weight, mass, size and conformation, rheological properties and for chemical identification, advancing the understanding of dispersed systems across many different industries and applications.
Headquartered in Malvern, UK, Malvern Instruments has subsidiary organizations in all major European markets, North America, China, Japan and Korea, a joint venture in India, a global distributor network and applications laboratories around the world. www.malvern.com
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