SCIEX advances its high-resolution accurate mass spectrometry portfolio with the launch of the ZenoTOF 7600+ system, accompanied by three new collaborations advancing proteomics capabilities.
The ZenoTOF 7600+ system features the cutting-edge ZT Scan DIA strategy, leveraging the combination of the quadrupole dimension with the rich MS/MS data achievable from the Zeno trap. The system aims to address a research gap—simplifying the transition of protein biomarker candidates beyond the discovery stage.
The system includes ZT Scan DIA, the latest evolution of data independent acquisition, making it the only system to encompass a multi-acquisition combination of DDA, DIA and targeted approaches within a single workflow. Results are achieving over 125% more quantifiable protein groups at sub-nanogram levels than conventional discrete-window DIA.
Meanwhile, the electron activated dissociation offers tunable fragmentation of all molecule types, further extending analytical capabilities. The ZenoTOF 7600+ is the fastest SCIEX accurate mass system with scanning speeds of up to 640 Hz, increasing the scope for large quantitation panels.
Additionally, researchers can expose a new dimension of data by mapping the MS/MS scans with the scanning Q1 quadrupole dimension, further increasing confidence and accuracy for the differentiation of isomeric peptides and localize post-translational modifications.
The ZenoTOF 7600+ system is compatible with PEAKS 12.5 from Bioinformatics Solutions Inc., the Evosep One from Evosep, and Aurora Series XS Range from IonOpticks to further propel key proteomics capabilities.