GPC Refractive Index Detector

GPC Refractive Index Detectors are one of the most commonly used detectors in gel permeation chromatography/size-exclusion chromatography. GPC RI detectors measure the refractive index of eluted compounds as they pass through the chromatographic column by comparing the sample to the pure solvent. The measured refractive index is directly proportional to its concentration, allowing the detector to provide quantitative data about the sample. When comparing GPC refractive index detectors ensure that the measurement range and sensitivity are sufficient for your assay as these can directly affect analysis and vary between models. For laboratories performing protein or polymer analysis, ensure that the temperature range is appropriate for your samples. When using a GPC refractive index detector always be sure to use high-quality solvents to achieve the best sensitivity. Thanks to their wide availability and good balance between sensitivity and ease of use, GPC RI detectors are an excellent option for most size-exclusion chromatography applications.