LC MS Instrument

Comprising two components, a liquid-phase separation system and a mass spectrometer, liquid chromatograph mass spectrometers (LC MS instruments) couple sample fractionation and analysis. The separation can be accomplished via standard liquid chromatography, HPLC, UPLC, or even nano-LC. Any liquid-phase separation will do, so long as its output can be directed into the mass analyzer (for instance, via an electrospray ionization source). The mass spectrometer is similarly flexible, ranging from the simplest single quadrupole to a Fourier transform ion cyclotron resonance instrument. Just remember, in a liquid chromatograph mass spectrometer the column flow is continuous, meaning the mass analyzer must be fast enough to thoroughly analyze one peak before the next one comes off the column. And, unlike with MALDI MS, once a peak is analyzed, it’s gone.
CompanySCIEXSCIEXSCIEXSCIEXSCIEX
ItemCitrine SystemEcho® MS+ systemSCIEX 7500+ SystemX500R QTOF systemZenoTOF 7600 system
Citations
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(1)
Catalog NumberEcho MS+SCIEX 7500+ SystemX500R QTOFZenoTOF 7600
Price
Ionization Method(s)Electrospray Ionization (ESI) and Atmospheric Pressure Chemical Ionization (APCI)Electrospray IonizationOptiFlow® Pro Ion SourceTurbo V ion source with twin sprayer ESI probe
and twin sprayer APCI probe
APCI and ESI modes
Mass AnalyzerTriple Quadrupole / QTRAP Hybrid (linear ion trap + triple quadrupole)Triple Quad or TOFTriple quadrupoleQTOFTOF
Scanning Speed1 ms MRM dwell times; 5 ms polarity switchingUp to 3 samples per second20,000 Da/sUp to 25 Hz (25 spectra per second)up to 25 Hz (25 spectra per second)
ResolutionInquireInquireUp to 3100 for mass 922 in LIT mode 1000 Da/s (0.3 Da)
Tune to a peak width of 0.5 Da for TQ mode
Equal to or greater than 42,000 (FWHM) measured on the (M+6H)6+ charge isotope cluster for bovine insulin at m/z 956Equal to or greater than 42,000 (FWHM) measured on the [M+6H]6+ charge isotope cluster for bovine insulin at m/z 956
DescriptionThe SCIEX Citrine MS/MS system is an in vitro diagnostic medical device providing the highest performance and reliability for demanding clinical diagnostics assays. Available in triple quadrupole and QTRAP versions, it delivers unparalleled sensitivity, high throughput, a wide dynamic range, and ... Read MoreThis ultra-high sample throughput system for Acoustic Ejection Mass Spectrometry (AEMS) delivers speed, scale, and reproducibility with unyielding data quality. The Echo® MS+ system leverages industry-leading quantitative MS technology from SCIEX to deliver a highly sensitive solution that can ... Read MoreInquireEngineered for standard biotherapeutic characterization analyses, the X500B QTOF system is a true benchtop instrument, with streamlined processing to get to a consistent, accurate view of your biologic. It is optimized for intact mass analysis, subunit analysis as well as high-quality peptide ... Read MoreA powerful leap in proprietary innovation, this high-resolution accurate mass system combines the power of Zeno trap pulsing with EAD fragmentation technology (electron activated dissociation) to uncover structural information, previously inaccessible, and drive the limits of quantification ... Read More
QuantityInquireEAEAEAEA
TypeTriple Quadrupole LC-MS/MS (IVD)InquireLC-MS/MSInquireInquire
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