| Description | Demonstrating that cell lines are monoclonal – or that a gene was edited as expected – can be a time-consuming and highly-subjective process when relying on conventional technologies. The CloneSelect® Imager and CloneSelect® Imager FL are a high-throughput automated solutions for imaging and Demonstrating that cell lines are monoclonal – or that a gene was edited as expected – can be a time-consuming and highly-subjective process when relying on conventional technologies. The CloneSelect® Imager and CloneSelect® Imager FL are a high-throughput automated solutions for imaging and analyzing mammalian cells. Tracking the formation of a colony from a single cell is effortless as barcoded plates are tracked over time. Automated acquisition and analysis provides accurate, objective, and consistent results.
With high-resolution white light imaging, the CloneSelect Imager provides automated confluence, monoclonality assurance and industry leading acquisition times with the ability to image a 96-well plate in under two minutes.
The CloneSelect Imager FL features high contrast multichannel fluorescent and white light imaging that allows for accurate single cell detection and proof of monoclonality at day 0. Streamline your workflow with comparative confluence assays to identify and verify gene edits.
Features : - White light and fluorescent imaging -
Image every well in every plate with rapid acquisition times with label-free white light. Multichannel fluorescence imaging provides additional confidence of monoclonality and comparative confluence assays (red vs green). - Data tools to accelerate research timelines -
The software automatically calculates confluence measurements and generates growth curves, heatmaps, and image montages. Measurements for every well are automatically tracked over time. Streamline multiple steps (imaging, sample tracking, data analysis and report generation) in the cell line development workflow for IND filing. - Quickly image a variety of plate formats and cell types -
Image a 96-well plate in under two minutes. Compatible with adherent or settled suspension cell types such as CHO, HEK, hybridomas, iPSCs, and many other cell types. - Intelligent analysis with easy-to-use software -
The software automatically calculates confluence for each imaging time point. Growth curve, image montage, total growth, and mean rate are generated automatically and are exportable. Guided software user interface allows for simple 1-hour training. - High-resolution images -
High-speed fluorescence and high-resolution white light imaging with accurate detection of single cells including debris. Image visualization and data tracking over multiple days. - Custom automation options -
The Automation and Customization Team offers a variety of custom services from robotic plate loading to fully automated workstations with liquid handling and incubation. We have built out custom automated work cells with the CloneSelect Imager for iPSC workflows, full assay systems and drug toxicity and characterization research.
... Read More | Digital microscopy with automated brightfield and fluorescence imaging.
The ImageXpress® Pico Automated Cell Imaging System is more than a digital microscope, combining high-resolution imaging with powerful analysis. Whether running fluorescence imaging or brightfield assays, the automated imagerDigital microscopy with automated brightfield and fluorescence imaging.
The ImageXpress® Pico Automated Cell Imaging System is more than a digital microscope, combining high-resolution imaging with powerful analysis. Whether running fluorescence imaging or brightfield assays, the automated imager features a comprehensive portfolio of preconfigured protocols for cell-based assays to shorten the learning curve, so you can start running experiments quickly.
Multiple imaging modes -
The ImageXpress Pico system offers objectives ranging from 4x to 63x and can operate in colorimetric, brightfield, or fluorescence imaging modes.
Preconfigured analysis protocols -
Preconfigured analysis protocols ranging from cell counting to sophisticated neurite tracing analysis removes the guess work from optimizing parameters.
Plate-to-individual cell view -
Data can be visualized at multiple levels from plate overview to individual cells. The cell click-to-find tool also makes it easy to automatically locate cells that match specific criteria.
Z-stack acquisition -
Z-stack acquisition enables the generation of sharper images and more accurate segmentation. A series of images acquired at different focal points captures more details than with an individual slice.
Advanced slide-imaging workflow -
Time and data storage can be saved by scanning an overview image of a whole slide; then, high resolution scans acquire only selected regions of interest.
Environmental control -
Multi-day, time lapse, and live cell assays can be run on the system. The software provides real-time monitoring of environmental state, ensuring optimal assay conditions. Product option includes humidity, CO2, and O2 control.
Other features and benefits include: - Get started quickly
- Do more than cell counting
- Image Economically
... Read More | The ImageXpress® HCS.ai High-Content Screening System captures your imagination with high-quality imaging and analysis, enabling you to acquire the data you need with ease. The system is configurable to match your requirements and can be upgraded as your research needs evolve. Empower your team to The ImageXpress® HCS.ai High-Content Screening System captures your imagination with high-quality imaging and analysis, enabling you to acquire the data you need with ease. The system is configurable to match your requirements and can be upgraded as your research needs evolve. Empower your team to obtain high-definition images and robust data from a wide range of 2D and 3D cell assays and leverage the power of AI for deeper insights.... Read More | Designed specifically for the SpectraMax® i3 Multi-Mode Detection Platform, the SpectraMax® MiniMaxTM imaging cytometer option adds first-of-its-kind cellular imaging capability to a microplate reader. The upgradable option makes cytometry more accessible to a wider audience, providing researchers Designed specifically for the SpectraMax® i3 Multi-Mode Detection Platform, the SpectraMax® MiniMaxTM imaging cytometer option adds first-of-its-kind cellular imaging capability to a microplate reader. The upgradable option makes cytometry more accessible to a wider audience, providing researchers with cellular analysis capability without the need for investment in complex imaging systems. With brightfield and fluorescent imaging modes, the imaging cytometry option enables quick inspection of cells and provides insight into phenotypic changes that are important for understanding cytotoxicity, cell proliferation, and protein expression.
Features - Simple workflow: Cell and whole-well assays in a small footprint
- More data: Multi-parametric cell-based assays with brightfield and fluorescent modes
- Familiar software: Set up, image and analyze cells in a snap using SoftMax® Pro Software
- Higher sensitivity: Use fewer and or less fluorescent cells compared to whole-well measurements
- Lower variance: Normalize readings with number of cells in a well
... Read More |