Capillary electrophoresis instruments enable to the separation of charged molecules from each other. Unlike standard SDS-PAGE separation, capillary electrophoresis systems can provide molecule detection after separation through a light source and detector and the system can utilize high voltages without overheating the samples. Applications for capillary electrophoresis instruments include pharmaceutical (i.e. digest analysis of biopharma drugs; peptide mapping), life science (i.e., protein/peptide separation, DNA analysis, and PCR product analysis, chemical (i.e. raw material analysis), forensics (i.e. drug and explosive analysis), environmental (i.e. pesticide analysis) and food/beverage (i.e. as organic acid analysis).
Consideration when purchasing a capillary electrophoresis system:
Capillary electrophoresis provides additional advantages over other analysis methods, like HPLC, GC, SDS-PAGE, which include speed, cost of analysis, and easy method development. First consideration is the type of system required. There are several methods of capillary electroseparation, which include capillary zone electrophoresis, capillary isoelectric focusing, capillary gel electrophoresis, and more. Second consideration is the system’s throughput; how many samples can the instrument run.
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Agilent Technologies
- Quantitative
- High molecular weight DNA, large DNA fragment libraries, BAC clones, low concentrated RNA and DNA sample QC, cfDNA
- 12 (per run)
Other Capillary Electrophoresis Instrument Products
Agilent Technologies
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- Next-Gen Sequencing libraries, PCR Fragments, Cell-Free DNA, Genomic DNA, total RNA, and IVT mRNA
- 12 to 96 samples
Agilent Technologies
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- Accurate purity assessments of ssDNA and ssRNA oligonucleotides without the use of dyes
- up to 96
Agilent Technologies
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- Protein sizing and quantification under reduced and non-reduced conditions; antibodies analysis, membrane, secreted, purified protein, and total protein extractions analysis
- 12 per run
Agilent Technologies
- Qualitative
- Genotyping, restriction digest analysis, PCR amplicon analysis, microsatellite detection
- 96 samples in less than 20 minutes
Promega
- Capillary Electrophoresis System
- Forensic DNA analysis, STR analysis, human identification, genetic identity testing, missing persons identification, sexual assault evidence analysis
- Up to four 96-well plates (384 samples); 8 capillaries, 36 cm array
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Qiagen
- Capillary Electrophoresis System
- DNA quality control, RNA quality control, genotyping, NGS library preparation
- 12 samples at a time, up to 96 samples per run
Qiagen
- Capillary Electrophoresis System
- DNA fragment analysis, RNA quality control, NGS library QC, cell-free DNA (cfDNA) QC, high-resolution genotyping, multiplex PCR screening, HLA typing, liquid biopsy, FFPE sample analysis
- Up to 96 samples per run (12 samples at a time)
Revvity
- Microfluidic Capillary Electrophoresis Nucleic Acid Analyzer
- DNA quality control, RNA quality control, NGS library QC, nucleic acid quantitation and sizing
- Up to 48 samples per run
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Revvity
- Microfluidic Capillary Electrophoresis System
- Protein sizing and purity (CE-SDS), charge variant analysis, glycan profiling, DNA analysis, RNA analysis, NGS library QC, biotherapeutics characterization, mAb analysis
- Up to 384 samples per run
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Thermo Fisher Scientific
- STR amplification kit
- Validated forensic DNA workflow for Human Identification
- Inquire
Bio-Techne
- Capillary Electrophoresis (CE) Instrument — imaged capillary isoelectric focusing (icIEF) and CE-SDS
- Protein purity, identity and charge heterogeneity analysis; cIEF (charge variants, pI determination); CE-SDS (size-based purity, heavy chain / light chain / NGHC content); mAbs, ADCs, fusion proteins, peptides, vaccines, virus-like particles; biopharmaceutical QC/QA, GMP/21 CFR Part 11 compliance
- Maximum 100 injections per batch (cIEF); maximum 48 injections per batch (CE-SDS PLUS); maximum 96 injections per batch (Turbo CE-SDS). Sample tray options: 96-well plates or 48 vials
Bio-Techne
- Capillary Electrophoresis (CE) Instrument — imaged capillary isoelectric focusing (icIEF) only
- Charge heterogeneity and identity analysis (cIEF/icIEF); pI determination; charge variant profiling of mAbs, ADCs, vaccines; biopharmaceutical QC/QA and method development; GMP/21 CFR Part 11 compliant environments
- 100 guaranteed injections per cartridge, 200 maximum; maximum 100 injections per batch. Sample tray options: 96-well plates or 48 vials
Bio-Techne
- Capillary Electrophoresis (CE) Instrument — CE-SDS (size-based separation) only
- IgG purity and heterogeneity analysis by size (CE-SDS); heavy chain, light chain, and NGHC content determination; mAb characterization; biopharmaceutical QC/QA and method development; GMP/21 CFR Part 11 compliant environments
- CE-SDS PLUS: maximum 48 injections per batch; Turbo CE-SDS: maximum 96 injections per batch. Sample tray options: 96-well plates or 48 vials
Helena Biosciences
- Capillary Zone Electrophoresis (CZE) Analyser
- Serum protein electrophoresis, immunodisplacement/immunotyping, hemoglobin analysis (HbA1c, UltraScreen), multiple myeloma screening
- 112 samples standard (up to 552 with Nexus MAX add-on); 14 racks of 8 primary tubes
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Helena Biosciences
- Capillary Zone Electrophoresis (CZE) Analyser
- Serum protein electrophoresis, multiple myeloma screening, immunodisplacement/immunotyping, urine protein analysis, whole blood hemoglobin analysis
- 112 onboard sample tube capacity (capped or uncapped)
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Prince Technologies
- Capillary Electrophoresis System
- Environmental analysis, forensics, pharmaceutical, food safety, life sciences; CE modes: CZE, CGE, MECC/MEKC, IEF, CEC, ITP; separation, identification and quantification from smallest ions to larger molecules
- Inlet: 50 sample positions (or optional 96-well plate with adapter); 50 buffer positions; outlet vial assembly
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Prince Technologies
- Capillary Electrophoresis System
- Environmental analysis, forensics, pharmaceutical, food safety, life sciences; CE modes: CZE, CGE, MECC/MEKC, IEF, CEC, ITP; separation, identification and quantification from smallest ions to larger molecules; fraction collection
- Inlet: 50 sample positions (or optional 96-well plate with adapter); 50 buffer positions; outlet autosampler: 20 positions
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Prince Technologies
- Capillary Electrophoresis System
- Environmental analysis, forensics, pharmaceutical, food safety, life sciences; CE modes: CZE, CGE, MECC/MEKC, IEF, CEC, ITP; separation, identification and quantification from smallest ions to larger molecules; fraction collection under precisely controlled conditions
- Inlet: 50 sample positions (or optional 96-well plate with adapter); 50 buffer positions; outlet autosampler: 20 positions
Inquire
Prince Technologies
- Capillary Electrophoresis System
- Environmental analysis, forensics, pharmaceutical, food safety, life sciences; CE modes: CZE, CGE, MECC/MEKC, IEF, CEC, ITP; separation, identification and quantification from smallest ions to larger molecules; fraction collection under precisely controlled conditions
- Inlet: 50 sample positions (or optional 96-well plate with adapter); 50 buffer positions; outlet autosampler: 20 positions
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SCIEX
- Capillary Electrophoresis (CE) System
- Inquire
- Inquire
Sebia
- Automated Capillary Electrophoresis System
- Serum Protein Electrophoresis (SPE), Serum Immunotyping, Urine Protein Electrophoresis (UPE), Urine Immunotyping, Hb A1c (venous blood & capillary blood), Hemoglobin Electrophoresis (adult blood), CDT & CDTIFCC
- 120 samples (15 racks of 8 positions each)
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Sebia
- Automated Capillary Electrophoresis System
- Serum Protein Electrophoresis (SPE), Serum Immunotyping, Urine Protein Electrophoresis (UPE), Urine Immunotyping, Hb A1c (venous blood & capillary blood), Hemoglobin Electrophoresis (adult blood), CDT & CDTIFCC
- 120 samples (15 racks of 8 positions each); MC configuration: up to 528 positions
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