Analysis of drugs using HPLC in pharmacokinetics studies and clinical tests is an effective means of elucidating the behavior of drugs and their metabolites in living organisms. Efficient sample pretreatment, for example, deproteinization, is critical to achieving reliable results. These procedures can be cumbersome and analytical accuracy can be compromised due to a reliance on manual operation; therefore, automated pretreatment procedures are preferable.

Enhancing Efficiency with Automation
Automatically and seamlessly conducting all processes from sample pre-treatment to analysis, the Prominence 2D HPLC for BA is a column-switching HPLC system equipped with the newly developed Shim-pack MAYI-ODS pretreatment column and a unique on-line dilution bypass channel. The system's on-line pre-treatment of bio-samples reduces labor while enhancing efficiency. A high-throughput autosampler provides high-speed injection and reproducibility. Accurate and precise temperature control of the system further ensures reproducible analysis and a high recovery rate.

This system serves as a front-end HPLC system for a mass spectrometer, enhancing the efficiency of analyzing drugs in biological samples for pharmacokinetics studies and clinical tests.