Thermo Fisher Scientific is pleased to announce a new method that can automatically extract glycoproteins from samples, and glycopeptides from tryptic digests, thus enabling faster isolation, better sample recovery, high peak efficiency, and high-throughput capability. Application Note (AN) 1014: Concanavalin A Column for Analysis of Glycoproteins and Their Tryptic Glycopeptides demonstrates that this approach enhances efficiency by leveraging innovative products. For example, this new method uses a high-performance liquid chromatography (HPLC)-compatible Concanavalin A (Con A) column that is built on a monolithic supportand offers advantages over other Con A columns.
AN 1014 also shows that a fully biocompatible analytical LC system can automate the entire off-line process, from sample enrichment and fraction collection to the reanalysis of collected sample by peptide mapping with both ultraviolet and mass spectrometry detections. Monitoring oxonium ions with a single quadrupole mass spectrometer is a selective, sensitive, and reliable method that confirms the identity of the glycopeptides captured by the Con A column.
This application note and many others can be found at www.thermoscientific.com/dionex under the Documents tab.
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