Flexible Benchtop Design Offers Label-free Molecular Interaction Analysis
EDISON, NJ July 9th, 2013 HORIBA Scientific, global leader in SPR Imaging, just announced the launch of OpenPlexTM, a powerful and flexible research platform for real time analysis of label-free molecular interactions in a multiplex format.
OpenPlex uses Surface Plasmon Resonance imaging (SPRi) to monitor the binding of molecules to an array of receptors immobilized on a sensor chip. It offers all the advantages of a conventional SPR system but allows measurements of up to hundreds of interactions in a single experiment. OpenPlex can give qualitative (Yes/No binding) and quantitative information of the interactions, such as concentration, affinity (KD), association and dissociation rates (kon, koff). Molecular interactions involving proteins, DNA, RNA, oligosaccharides, living cells, polymers or nanoparticles can be characterized and quantified.
OpenPlex is compatible with MALDI-TOF mass spec analysis, enabling secondary identification of species for “ligand fishing” experiments.” In situ trypsin digestion MALDI provides protein mass fingerprinting.
OpenPlex is an enhanced redesign of our flexible compact and manual label-free SPRi-Lab+. The new design will facilitate cutting edge research, from nanotechnologies, physical chemistry, biochemistry, biomedical research, and biology. It has a smaller footprint and integrates the fluidics system into a compact enclosure.
The new configuration also allows for simultaneous fluorescence and electrochemistry experiments to be performed on OpenPlex. An optical window design allows fluorescence information to be gathered either from the ensemble of experiments or individually with a microscope. An open ‘cuvette’ configuration allows for OpenPlex to monitor electrochemical deposition of material.
“OpenPlex extends the multiplex advantage of our SPRi technology. The flexible architecture featuring different flow cell configurations makes it simple to combine label-free molecular interaction analysis with fluorescence or electrochemistry” said Ishai Nir, Director of Fluorescence for HORIBA Scientific“
OpenPlex is currently available. More information can be found at: http://www.horiba.com/us/en/application/material-property-characterization/water-analysis/details/openplex-flexible-surface-plasmon-resonance-imaging-system-74/
About HORIBA Scientific
HORIBA Scientific, part of HORIBA Instruments, Inc., headquartered in the United States, provides an extensive array of instruments and solutions for applications across a broad range of scientific R&D and QC measurements. HORIBA Scientific is a world leader in elemental analysis, fluorescence, forensics, GDS, ICP, particle characterization, Raman, spectroscopic ellipsometry, sulphur-in-oil, water quality and XRF. Our instruments are found in universities and industries around the world. Proven quality and trusted performance have established widespread confidence in the HORIBA Brand.
The HORIBA Group of worldwide companies, part of HORIBA, Ltd. headquartered in Kyoto, Japan, provides an extensive array of instruments and systems for applications ranging from automotive R&D, process and environmental monitoring, in-vitro medical diagnostics, semiconductor manufacturing and metrology, to a broad range of scientific R&D and QC measurements.
Contact:
Joanne Lowy
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HORIBA Scientific
HORIBA Instruments, Incorporated
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Edison, NJ 08820-3012
732-494-8660 ext. 8142 / Direct Line: 732-623-8142