Particle Size Analyzer (Particle Analyzers / Particle Sizer)

Particle analyzers are used to determine the size and distribution of particles making up a material. Particle size analyzers are used in numerous fields for research and development, manufacturing and for quality control and product testing. Different technologies enable analysis across a wide range of sizes, of particles in powder, liquid, aerosol or other forms, and of materials ranging in diversity from soil, paint and cosmetics to nasal spray and proteins.

Laser diffraction particle size analyzers calculate particle size from the angle of light scattered by a stream of particles passing through a laser beam. This technique allows for continuous measurement of bulk material across a wide size range (10 nm to 3 mm). The size limits and sensitivity of a laser diffraction particle analyzer depend on the number and placement of detectors in the instrument. Dynamic light scattering particle analyzers are mainly used for analyzing particles in solution (size range: 1 nm to 6 um). Dynamic light scattering determines size from the fluctuations in scattered laser light intensity created by the particles’ Brownian motion. Induced grating particle size analyzers identify the size of even smaller particles (0.5 nm to 200 nm) in solutions by electrically aligning the particles and then measuring their diffusion.

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DAWN&trade; Multi-angle Light Scattering (MALS) Instrument
Waters | Wyatt Technology
  • Particle Size:
    Inquire
  • Detector(s):
    High-gain, high-dynamic-range photodiodes at 18 angles for MALS; optional avalanche photodiode that may be placed at any of four angles for DLS.
    Fluorescence-blocking filters available for use with analytes that fluoresce when illuminated at the MALS wavelength.
  • Measuring Time:
    Depedent on LC separation
  • Applications:
    With standard SEC/GPC or EclipseTM (FFF system): determination of distributions of molar mass, size, conformation, conjugation ratio and particle concentration. With Calypso composition-gradient system: label-free characterization of biomolecular interactions including self- and hetero-association as well as non-specific interactions.
DynaPro&trade; NanoStar&trade; II Dynamic Light Scattering Instrument
Waters | Wyatt Technology
  • Particle Size:
    0.2 to 1000 nm
  • Detector(s):
    Inquire
  • Measuring Time:
    Inquire
DynaPro&trade; Plate Reader III Dynamic Light Scattering Instrument
Waters | Wyatt Technology
  • Particle Size:
    0.5 to 1000 nm
  • Detector(s):
    Linearized avalanche photodiode for dynamic and static light scattering
  • Measuring Time:
    Measurement Time: 5 to 60 seconds per well
    830 nm
  • Applications:
    Develop stable biopharmaceuticals, assess viral vector titer and aggregation, optimize protein buffers for crystallization, SAXS or chromatography, formulate theranostic nanoparticles, discover small-molecule and peptide inhibitors of protein-protein interactions
Citations:
(4)
DynaPro&trade; ZetaStar&trade; Dynamic, Electrophoretic, and Static Light Scattering Instrument
Waters | Wyatt Technology
  • Particle Size:
    0.2 to 1000 nm
  • Detector(s):
    Inquire
  • Measuring Time:
    15 seconds typical
  • Applications:
    Analysis of proteins, gene vectors, viruses and virus-like particles, promiscuous inhibitors, micelles, nano-emulsions, lipid and metallic nanoparticles, and more.
microDAWN&trade; Multi-Angle Light Scattering Instrument for UHP-SEC-MALS
Waters | Wyatt Technology
  • Particle Size:
    Inquire
  • Detector(s):
    High-gain, high dynamic range, static light scattering detectors at 3 angles
  • Measuring Time:
    Depedent on LC separation
  • Applications:
    With SEC/GPC: determination of distributions of absolute molar mass, size, conformation, conjugate ratio.
Citations:
(1)
miniDAWN&trade; Multi-Angle Light Scattering (MALS) Detector for SEC-MALS
Waters | Wyatt Technology
  • Particle Size:
    Inquire
  • Detector(s):
    High-gain, high-dynamic range photodiodes at 3 detection angles for MALS. Optional avalanche photodiode for simultaneous dynamic light scattering measurements.
  • Measuring Time:
    Depedent on LC separation
  • Applications:
    With SEC/GPC: determination of distributions of absolute molar mass, size, conformation, conjugate ratio. With Calypso CG-MALS: characterization of biomolecular interactions.
Citations:
(333)
WyattQELS™ Light Scattering Detector Module
Waters | Wyatt Technology
  • Particle Size:
    Flow mode: 1 nm to 40 nm (TREOS); 1 nm to 300 (HELEOS)
    Batch mode: 10 to 50 nm; 0.5 nm to 1 µm (cut 10 to 50 nm)
  • Detector(s):
    Avalanche photodiode coupled to a multimode optical fiber
  • Measuring Time:
    Measurement Time: 0.1 to 3600 sec
    Same as MALS host instrument
  • Applications:
    High-resolution size distributions with fractionation by SEC or FFF; conformation when combined with MALS molar mass and/or size data
Citations:
(46)
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  • Waters | Wyatt Technology
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