Dissolution Sampler / Dissolution Sampling System

Dissolution testing is an important measure of the ability of a drug to dissolve in solution – the first step in a pill's administration. But most pills are heterogeneous, and it is not always clear if the active ingredient is dissolving as well as the inactive ones. Dissolution sampling systems analyze the process of dissolution. Like most dissolution testing systems, a dissolution sampling system can employ up to seven standardized apparatuses approved for use by the U.S. Pharmacopeia: baskets, paddles, reciprocating cylinders, flow through cells, paddle over disk types, cylinders, and reciprocating holders. The dissolution sampling system then analyzes the in vitro dissolution of the capsule or pellet's constituent compounds over time, as well as their movement through solution. This can either be accomplished by an internal optical system or by interfacing the dissolution sampler with an HPLC system. Consequentially, many dissolution samplers are designed to be compatible with HPLC systems from that manufacturer.