Quotient Clinical Showcases Four Poster Publications at AAPS

20 September 2012 – Quotient Clinical, a leading provider of specialist early stage drug development services, will present four significant poster publications at the forthcoming American Association of Pharmaceutical Sciences (AAPS) meeting and exposition to be held from October 14th to 18th in Chicago, USA.

The first publication, co-authored with Merck Serono, is entitled Development of a Formulation Design Space to Enable Real-Time Optimization of a Modified Release (MR) Tablet Composition within a Flexible Clinical Study and examines how MR tablet formulations can be developed to enable assessment in humans in a single, flexible RapidFACT™ clinical study to identify an optimal once/twice daily product.

Co-authored with scientists from Ardrea Biosciences and L’Université de Montreal, the second publication entitled Rapid Clinical Screening of a Nanosized Poorly Soluble Drug Substance as an Alternative Means to Achieve Extended Release evaluates a nanosized Immediate Release (IR) tablet formulation as a strategy to achieve a once-a-day product via dissolution-controlled release.

The third publication: Applications of Exploratory Clinical Trials in Drug Development: Review of Exploratory Trial user Group Meeting, Washington DC, June 2011, co-authored with scientists from seven leading pharmaceutical companies; AstraZeneca, Bristol-Myers Squibb, GlaxoSmithKline, Merck, Novartis, Pfizer and Takeda, reviews the proceedings of a user group meeting that discussed the impact of ICH M3 exploratory clinical trials guidance on conventional drug development paradigms.

Co-authored with scientists from GlaxoSmithKline and entitled Applications of the Entero-Test® Bile String for Accessing Biliary Excretion of GSK962040 and its Metabolites in Healthy Subjects, the fourth publication describes the combined application of Quotient’s ivMicrotracerTM technology with Entero-Test® duodenal sampling to study the biliary elimination of GSK962040 (a selective motilin agonist).

Details of the publications are: Development of a Formulation Design Space to Enable Real-time Optimization of a Modified Release (MR) Tablet Composition within a Flexible Clinical Study Poster Session I (Abstract ID: 104, Poster ID: T2130) Date: Tuesday, October 16, 2012 Time: 09:30am – 12:30pm Location: Hall F

Rapid Clinical Screening of a Nanosized Poorly Soluble Drug Substance as an Alternative Means to Achieve Extended Release Poster Session I (Abstract ID: 2419, Poster ID: W5053) Date: Wednesday, October 17, 2012 Time: 01:30pm – 04:30pm Location: Hall F

Applications of Exploratory Clinical Trials in Drug Development: Review of Exploratory Trial user Group Meeting, Washington DC, June 2011

  • Poster Session I (Abstract ID: 2088 Poster ID: T3349)
  • Date: Tuesday, October 16, 2012
  • Time: 01:30pm - 04:30pm
  • Location: Hall F

Application of the Entero-Test® Bile String for Accessing Biliary Excretion of GSK962040 and its Metabolites in Healthy Subjects Poster Session II (Abstract ID: 1214, Poster ID: T2307)

  • Date: Tuesday, October 16, 2012
  • Time: 09:30am - 12.30pm
  • Location: Hall F

Quotient will be located at exhibition booth #2530 to discuss your drug product optimization needs. Should you wish to arrange a meeting, please email [email protected]

For further information, please contact:

Sam Metcalf
bcsAgency
Tel: 0115 9486900
Email: [email protected]