AUSTIN, Texas (March 24, 2011) - Thermo Fisher Scientific Inc., the world
leader in serving science, today announced an innovative new method for the
detection and absolute quantification of metabolites based on the Thermo
Scientific TSQ Quantum XLS in multiple reaction mode (MRM). Using this
advanced triple stage quadrupole GC-MS/MS-MRM technology, scientists are now
able to conduct both discovery phase analysis and selective identification
and quantification analysis with a single instrument. The high sensitivity
and selectivity of the method enables scientists to effectively study plant
metabolism and perform phytohormone profiling. The new method is detailed in
an application note entitled "Metabolomics strategies using GC-MS/MS
technology," available to download via www.thermoscientific.com/biometa
Success in metabolomics, a relatively new area of study that observes the
unique chemical fingerprints that cellular processes leave behind, is
heavily influenced by the capabilities of analytical instrumentation. This
is largely due to the physio-chemical diversity of biological small
molecules. Varied and flexible analytical strategies such as GC-MS, LC-MS &
MS/MS are therefore essential and often need to be combined. Analysis of low
concentration endogenous metabolites in complex biological samples is often
challenging due to the chromatographic co-elution of different components.
The use of LC or GC-MS/MS strategies is necessary to improve the selectivity
of targeted metabolomics assays.
The TSQ Quantum XLS extends the market-leading range of Thermo Scientific
mass spectrometry solutions for metabolomics applications, delivering the
necessary mass accuracy, resolution and speed required to provide sensitive,
high quality quantitation in metabolomics studies. The ability to use a
single instrument when performing both the screening and quantitation of
metabolites not only accelerates the process, thereby increasing throughput,
but also provides optimized reproducibility in fragmentation pattern, peak
intensities and mass accuracies. In addition, compounds which typically
cannot be separated through gas chromatography can be separated using
compound-specific MRM transitions in a single run.
The TSQ Quantum XLS features the innovative Thermo Scientific DuraBrite IRIS
ion source, which ensures high sensitivity in the low femtogram range,
excellent quantitative precision at trace levels and uninterrupted operation
for increased productivity. In addition to offering maximum precision,
sensitivity and laboratory productivity for quantitative GC-MS analysis, the
TSQ Quantum XLS offers the unique ability to combine full scan MS analyses
of metabolites and targeted analysis. Using the TSQ Quantum XLS, metabolome
coverage can be achieved with accurate and selective identification and
quantification, while achieving high sample throughput.
For more information about the Thermo Scientific TSQ Quantum XLS triple
quadrupole GC-MS, please call 1-800-532-4752, e-mail [email protected] or
visit www.thermoscientific.com/quantumxls
About Thermo Fisher Scientific
Thermo Fisher Scientific Inc. (NYSE: TMO) is the world leader in serving
science. Our mission is to enable our customers to make the world healthier,
cleaner and safer. With revenues of nearly $11 billion, we have
approximately 37,000 employees and serve customers within pharmaceutical and
biotech companies, hospitals and clinical diagnostic labs, universities,
research institutions and government agencies, as well as in environmental
and process control industries. We create value for our key stakeholders
through two premier brands, Thermo Scientific and Fisher Scientific, which
offer a unique combination of continuous technology development and the most
convenient purchasing options. Our products and services help accelerate the
pace of scientific discovery, and solve analytical challenges ranging from
complex research to routine testing to field applications. Visit www.thermofisher.com
Media Contact Information:
Name: Lindsay Baldry
Phone: +44 1477 539539
E-mail: [email protected]
Secondary Contact Information:
Michael Nelson
(512) 251-1527
[email protected]