Bio-Rad Laboratories’ prepacked process-scale Foresight Pro chromatography columns packed with scalable Nuvia chromatography resins are ideal for downstream process-scale chromatography applications throughout the various stages of biological drug development and manufacturing.
The extended range includes columns packed with anion exchangers (AEX) Nuvia Q Media and Nuvia HP-Q Media, cation exchanger (CEX) Nuvia HR-S Media, and mixed-mode (MM) resins Nuvia cPrime Media, a CEX-hydrophobic interaction chromatography (CEX-HIC) resin, and Nuvia aPrime 4A Media, an AEX-HIC chromatography resin. These options expand the existing family of Foresight Pro columns packed with CHT Ceramic Hydroxyapatite Media Type I, Type II, and XT, which have been incorporated into various regulatory-approved processes worldwide.
Columns prepacked with Nuvia resins are now available with internal diameters (ID) of 5 to 13 cm and bed heights of 10 and 20 cm. Columns with IDs of 20 to 45 cm are also in development with anticipated availability in early 2027.
Nuvia chromatography resins use Bio-Rad's Nuvia bead technology, featuring a polyacrylamide (acrylamide polymer) base bead suitable for laboratory-scale purification, process development, pilot-scale production, and commercial biomanufacturing applications. Bio-Rad’s Nuvia resins are designed to have minimal non-specific binding reactions, due to the hydrophilic nature of the bead polymer, and maintain a constant dynamic binding capacity over a wide range of flow rates.
The Nuvia bead allows for fast mass transfer and is chemically and mechanically stable over a wide range of conditions. All Bio-Rad Foresight Pro Columns are manufactured in a controlled ISO Class 7 cleanroom, providing good manufacturing practice (GMP) ready columns. The prepacked columns' standardized design and format can provide a more cost-effective and flexible solution than customer-packed columns, and columns are available in a range of diameters and bed volumes.