European premiere at HPLC show in Budapest /
World’s fastest sample injection, absolute lowest carry-over /
Quick analysis of multiple samples with high accuracy
Shimadzu, one of the worldwide leading manufacturers in analytical
instrumentation, has introduced the Nexera MP UHPLC as a Front
End system for LC/MS. The system premiered in Europe at the
HPLC 2011 show in Budapest, Hungary, from June 19 to 23. The
Nexera MP is perfect for LC/MS analysis conducted in
pharmacokinetics and synthesis stages in drug detection processes.
SIL-30ACMP Multiplate Autosampler with optional
CTO-30AS Column Oven
The new SIL-30ACMP Multiplate Autosampler used in the Nexera
MP is best suited for LC/MS analysis and has the industry-best
micro-volume injection repeatability, the world’s highest injection
speed and the lowest carryover. Combining the Nexera MP with
Shimadzu’s LCMS-8030 Triple Quadrupole Mass Spectrometer or
the LCMS-2020 Single Quadrupole Mass Spectrometer creates a
system for quick analysis of multiple samples with high accuracy.
Development Background
Pharmacokinetics and candidate compound synthesis stages in drug
discovery processes need fast analysis of multiple samples using an
LC/MS system with high throughput. Minimization of carryover in
2
samples is also important for enhancement of LC/MS analysis
reliability, since mass spectrometers are becoming more and more
sensitive.
The synthesis stage demands a system where two or more users can
share an instrument and measure samples without delay, so that
candidate compounds can be checked and identified quickly for more
efficient analysis. This setup also reduces power consumption,
thereby lessening the burden on the environment.
Outstanding features
Combined with high-performance accessories, the Nexera MP
UHPLC Front End system achieves outstanding features:
- Efficient sample preparation
The SIL-30ACMP Multiplate Autosampler provides excellent
injection repeatability with micro volume injections (e.g. 1%
max. in 0.5 μL injections). The influence of sample solvents,
which causes problems in analysis of deproteinized or synthetic
samples, is minimized by reducing the injection volume.
Samples can therefore be injected directly without dilution,
streamlining the preparation process. - Multi-sample processing with the world's fastest injection
In addition to fast separation of components, the Nexera MP
uses the SIL-30ACMP Multiplate Autosampler featuring the
world’s fastest injection at just 7 seconds which enables ultrahigh-
speed analysis cycles. In addition, up to 2304 samples can
be set. Ultra-high-speed multi-sample processing is enabled,
necessary in pharmacokinetics and synthesis confirmation
processes. Ultra-high-speed analysis reduces consumption of
both power and organic solvents used for analysis, reducing in
turn the environmental burden. - Industry-lowest level carryover
The Nexera MP provides ultra-low carryover, essential for
3
LC/MS analysis. By incorporating the exceptional technology
used in the Shimadzu prominence / Nexera Series autosamplers
to effectively prohibit adsorption in the sample line, the SIL-
30ACMP achieves an industry-lowest level carryover of 0.0015
% max. (no rinse). A multi-rinse function allows selection of
the optimum rinse method depending on the sample. These
functions ensure reliable analysis even when a high-sensitivity
mass spectrometer is used. - Two or more analyzers share one system
Two or more experimenters often share one system in the
compound confirmation process. Using the Nexera MP, each
can set a sample plate without delay, even during analysis.
Analyses previously run in multiple systems can therefore be
run on one system, saving energy and operation costs. - Column oven setting to the MS position
To achieve ultra-high-speed analysis using LC/MS, the length of
the piping connecting the HPLC and mass spectrometer needs to
be minimized in order to fully exploit the separation
performance. When mounting the optional CTO-30AS Column
Oven to the autosampler, mounting height can be adjusted in
three steps and the angle can be adjusted flexibly. As a result,
the column exit can be positioned according to the height of the
LC/MS interface, helping to realize ultra-high-speed, highseparation
LC/MS analysis while maximizing the system’s
separation performance.
The Nexera MP is controlled by Shimadzu’s LabSolutions software
and major LC/MS workstations available from other companies.
Contact:
Uta Steeger
Shimadzu Europa GmbH
Albert-Hahn-Str. 6-10
47269 Duisburg
Tel.: +49 (0) 203-7687-410
e-mail: [email protected].
Additional information is available on Shimadzu’s website: www.shimadzu.eu
Download is possible via http://shimadzu.eu/press
Follow us on twitter: http://twitter.com/ShimadzuEurope