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A New Crop of Columns
Tuesday, January 30, 2018
In 1900, Russian-Italian botanist Mikhail Semyonovich Tsvet invented liquid chromatography. Read More
Best Practices When Changing From HPLC to TOC Analysis for Cleaning Validation
Thursday, January 18, 2018
Historically, HPLC has been the most common analytical method for quantitation of residual active pharmaceutical ingredients (APIs) for cleaning validation (CV) of pharmaceutical production equipment. Read More
Product Contamination Visualization and Identification Using FTIR Microspectroscopy
Friday, September 29, 2017
Fourier transform infrared (FTIR) microspectroscopy is a preferred method for the analysis and identification of contaminants, fibers, and other microsamples. Read More
Bioparticles, Molecules, and Complexes Analyzed by “Chromatography” Without a Stationary Phase
Friday, September 29, 2017
Students learn that chromatography involves interactions of analytes with stationary phase and mobile phase, just as it was designed by Mikhail Tsvet more than a century ago. Read More
Automated Nephelometric Turbidity Measurement of Biotherapeutics Formulations
Friday, September 29, 2017
Turbidity is one of many physical properties of biotherapeutics formulations monitored during drug discovery and development to assess drug stability. Read More
Ion-Moderated Partitioning for Carbohydrate Analysis
Friday, September 29, 2017
Carbohydrate analysis using HPLC separation techniques includes two options: normal-phase and reversed-phase. Read More
Automated Glucose Control
Tuesday, September 05, 2017
One goal of mammalian upstream bioprocess development is to deliver a process that is safe and robust and that produces enough biopharmaceutical material to meet demands. Read More
A Virtual Instrument System for Testing the Validity of Drugs
Tuesday, September 05, 2017
A virtual instrument (VI) system developed for measuring the validity period of drugs is based on a graphical programming language. Read More
Potential of 3-D Cell Culture in Research and Therapy
Tuesday, September 05, 2017
Three-dimensional cell culture has played a steadily growing role in drug discovery since the technology’s inception more than two decades ago. Read More
Molecular Motions
Friday, August 18, 2017
Infrared light stirs vibrations in molecules, and how they shake reveals what they are. Read More
Long-Range Genomics is Reviving a Lost Art
Wednesday, July 26, 2017
Next-generation sequencing (NGS) tools helped bring sequencing into the high-throughput realm, but suffer from the limitations of short reads. Read More
A Real-Time Concentration Monitor for Flowing Streams
Wednesday, July 26, 2017
Many continuous processes require frequent sample extractions and off-line analyses to optimize methods and monitor processes. Read More
NMR’s New World
Thursday, June 22, 2017
To determine the structure of an organic sample, chemists often turn to nuclear magnetic resonance (NMR). Read More

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